The Study On Significance Of Biomarkers In Salivary Of Patients With OSAHS

【Backgroud】Noctunal sweating and hypertension may appear as results of the sympathetic nerveexcitement. Nocturnal sweating is one of the chief complaints in patients withOSAHS. Studies have reported34-50%of the OSAHS patients are combined withnocturnal sweating. Presently, there is a shortage of relevant domestic research.Nocturnal hypertension is the most common cardiovascular injury in OSAHS.Salivary amylase can indicate the sympathetic nerve excitement status from anotherprespective, which can be applied as a non-invasive and sensitive indicator. Salivarycortisol, because of the convenient and non-invasive access of sampling, theapplication is relatively mature in clinical practice of estimating HPA. However it isstill not well-known about the significance of these two biomarkers among OSAHSpatients.【Objective】The test is designed to observe the characteristics of frequent nocturnal sweating andhypertension in obstructive sleep apnea hypopnea syndrome (OSAHS) patients andto discuss whether the level of salivary amylase and salivary cortisol are related tohypertension or frequent nocturnal sweating in OSAHS patients. As well as toevaluate the clinical value of salivary amylase as a biomarker.【Methods】47subjects with OSAHS were enrolled in the study, who were diagnosed by polysomnography (PSG) in Sleep Medical Center Of Ruijin Hospital betweenOctober2013to March2014. Medical history, blood pressure and salivary samples,etc. were collected for all participants. According to the hypertension or frequentnocturnal sweating, subjects were divided into two types of groups: hypertensionand non-hypertension groups, frequent-sweating and seldom-sweating groups.Comparison of characteristics included general information, PSG parameters, andblood pressure. The correlation between the aboved indexes and salivary test resultswere analysed.【Result】(1)Salivary amylase level in OSAHS patients increased significantly withpositive correlation with AHI.(2) Salivary amylase level in hypertension group was significantly higher thanin non-hypertension group.And a positive correlation between salivary amylaselevel and nighttime systolic blood pressure was showed.(3) The OSAHS patients had an obvious tendency to sweat at night. Salivaryamylase level in frequent-sweating group was significantly higher thanseldom-sweating group.(4) Based on these two types of classification, no difference was found insalivary cortisol levels in all groups.【Conclusion】(1)Salivary amylase level is associated with AHI, which can reflect OSAHSseverity.(2)Salivary amylase can be used as a noninvasive, convenient way to evaluatesympathetic nerve excitement in patients with OSAHS, which can also reflectthe nighttime blood pressure.(3)Salivary cortisol level in OSAHS patients has no correlation withhypertension and frequent nocturnal sweating.