Application Value Of HbA1c And GA In Liver Cirrhosis With Hyperglycemia Patients

Objective:We apply HbA1c and GA to monitor blood glucose in liver cirrhosis withhyperglycemia patients and type2diabetes patients in this study, then, compare andanalyze the difference about the blood glucose monitoring effect, to research theapplication value of HbA1c and GAin liver cirrhosis with hyperglycemia patients.Object and Methods:Select100cases of liver cirrhosis with hyperglycemia patients as the researchobject (liver cirrhosis with hyperglycemia group), divided into anemia and no-anemiagroup at the point of hemoglobin (Hb)110g/L, the no-anemia group was divided at thepoint of serum albumin30g/L;100cases of type2diabetes without liver cirrhosispatients as control group(type2diabetes group); All patients were detected withHbA1c, GA, fasting plasma glucose (FPG),2hPG, liver function, blood lipid, bloodroutine test and so on, the data were collected for statistical analysis. To research therelationship between HbA1c、GA and blood glucose levels and related metabolicindices in all groups.Results:1.The HbA1c level was compared between liver cirrhosis with hyperglycemiagroup and type2diabetes group, the HbA1c level in liver cirrhosis with anemia is lower than that in type2diabetes group(6.76±2.20%vs7.34±1.23%，P=0.06), has thetrend of statistical difference, but the level of GA were significantly higher than that intype2diabetes group(19.10±7.47%vs16.68±2.90%，P＜0.01). With or withoutanemia, the level of2hPG in liver cirrhosis with hyperglycemia group wassignificantly higher than that in type2diabetes group(12.09±3.39%12.39±3.75%vs10.84±2.95%，P＜0.05).2. The GA level was compared between liver cirrhosis with hyperglycemiagroup(with the exception of anemia) and type2diabetes group, the level of GA inALB＜30g/L group was obviously higher than that in30≤ALB<40g/L group and type2diabetes group(18.79±2.28%vs16.71±2.42%vs16.73±2.96%, P＜0.01), the GAmeasurement which was compared with type2diabetes patients is about12%overvalued.3. The level of GA and HbA1c between liver cirrhosis without anemia andhypoproteinemia group and type2diabetes group has no significant difference (P>0.05).4. HbA1c has a positive correlation with FPG in liver cirrhosis withhyperglycemia group and type2diabetes group, r values were0.45(P＜0.001),0.76(P＜0.001), HbA1c also has a positive correlation with2hPG, r values are0.33(P=0.001),0.81(P＜0.001). GA has a positive correlation with FPG in liver cirrhosis withhyperglycemia group and type2diabetes group, r values are0.48(P＜0.001),0.74(P＜0.001), respectively, GA also has a positive correlation with2hPG, r values are0.39(P＜0.001),0.76(P＜0.001), respectively; GA has a negative correlation with ALB inliver cirrhosis with hyperglycemia group, r value is-0.28(P=0.032).Conclusions:For liver cirrhosis with hyperglycemia patients, the index which monitors blood glucose should be noticed:1.For patients with anemia(Hb＜110g/L), it is unfavorable to use HbA1c toevaluate the blood glucose level.2. For patients with hypoproteinemia(ALB＜30g/L), it is unfavorable to use GAto evaluate the blood glucose level.