Influence Of Genetic Mutations On Clinical Onset And Prognosis In Patients With Dilated Cardiomyopathy

Objective:Idiopathic dilated cardiomyopathy (IDCM) is a common disease and characterized by ventricular expansion, decreased myocardial contractile function.IDCM is the most common cause of heart failure and heart transplantation in the young.The pathogenesis of idiopathic dilated cardiomyopathy is not yet clear. For nearly 10 years, with the continuous development and progress of molecular genetics technology, researchers have discovered that gene mutation is associated with IDCM in its etiology and pathogenesis. These genes code neurohumoral factors which regulating cardiac function and myocardial fibers.The genotype-phenotype correlation analysis may provide a new risk-stratification instrument in patients with IDCM,however,there is no report about the difference in clinical data and prognosis between the mutation carriers and non-carriers in the IDCM patients in China.This article detected gene sequence and analyzed the clinical data of the IDCM patients in our hospital to investigate the correlation between genetic mutation and clinical onset and prognosis.Method:A total of 115 IDCM patients who were admitted to our hospital from January 2011 to September 2014 were enrolled and received serum biochemical test、 electrocardiographic、X-ray、echocardiographic and gene sequencing.They whole accept heart failure treatment and antiarrhythmic therapy.These patients were divided into mutant group (n=29) and not mutant group (n=86) after gene sequencing. The primary end point are hospital readmission and all cause motality.The clinical data and end points were compared.Results:There is no difference in hospital readmission and all cause motality between the two groups.Comparisons between the two groups showed no significant difference in baseline characteristics such as gender, age of symptom onset, blood pressure, and diabetes.Meanwhile, no difference was shown in the left ventricular ejection fraction (LVEF), left ventricular diastolic diameters (LVDD), QRS-T angles, serum creatinine level, pharmacotherapy and device implantation.Conclusion:There is no significant difference in clinical data and end points between the two groups.