The New Progress Of Endothelial Progenitor Cells Treatment Of Pulmonary Hypertension

Pulmonary hypertension is a disease characterized by pulmonary vasoconstriction, pulmonary vascular remodeling and in situ thrombosis, resulting in pulmonary vascular resistance increasing and blood flow restriction,pulmonary artery pressure elevating, eventually leading to right heart dysfunction, even death.Remedy of the integrity of endothelial structure and function, pulmonary vascular remodeling, angiogenesis replace permanent vascular occlusion, is the key to the treatment of PH. Recent studies have found that normal endothelial progenitor cells play an important role in maintaining vascular homeostasis and reversal pulmonary vascular remodeling and promote angiogenesis,can be used for the treatment of ischemic diseases. but some pathologic state, the function of EPCs dysfunction, may participate in the pulmonary vascular remodeling,promote the progress of pulmonary hypertension.This article makes a summary on the EPCs for the treatment of PH.