| Objective: As the ingravescence of aging population, the prevalence of osteoporosis increased year by year, which lead to a high morbidity and mortality. Recently, several studies demonstrated that overall incidence of osteoporosis was 22.6% in the people over 60 yr in China. The incidence of osteoporosis was 15.0% in the male and 8.6% in the female. But it tends to be increasing year by year. Owing to the decline to various degrees at proprioceptive sensibility and mobility, the risk of falls is greatly increasing in the old patients with several chronic diseases. Therefore, the major factors which influence the prognosis of the old osteoporosis patients are the related complications after fracture. There are about 37,500 patients died from the related complications of osteoporotic fracture in USA. Recently, clinical researches focus on senile osteoporosis. At present, two categories of drugs to treat osteoporosis are the drugs promoting bone formation and inhibiting bone resorption. The basis of the treatment on osteoporosis is sufficient calcium and activated vitamin D supplementation.Balance function appeared a series of degenerative changes with age. These changes in balance function are likely to contribute to an increased risk of falls, leading to the occurrence of fracture, the decline in the quality of life and the shortening of lifespan. It was observed that the obvious descent of the balance function appeared after 60 years old. Keeping balance function well should coordinate some influence factors, such as vestibular, muscle, joint, vision, proprioception and so on. It can be divided into static balance function and dynamic balance function. Hypofunction appeared in the postural control, muscle, joint, ligament and flexibility. This is especially apparent in the old people. It became a hot spot of research that the use of balance function evaluate and prognosticate the risk of falls. There are many ways to evaluate balance function, such as observational method, scaling method and the experimentation method. Additionally, experimentation method includes many ways to exam the static balance function and the dynamic balance function. Stork stand test(SST) and star excursion balance tests(SEBT) were widely used in clinics without any geographic restriction and the instrument limitation.In this context, the objectives of our study were to investigate the effects on bone mineral density and balance function and the pain of bone before and after treatment on the patients with senile osteoporosis by oral Calcium and Vitamin D. In addition, there were linear correlations or not between the age and BMD, SST, SEBT and between right femur BMD and SST, SEBT.Methods: A total of 86 patients who were first diagnosed with senile osteoporosis and were accorded with the inclusion criteria were randomly selected in our study from March 2014 to December 2014. We recorded the gender, age, height, weight limb length and other related informations of patients, calculated body mass index(BMI); Bone mineral density(BMD) was examined by dual energy X-ray absorptiometry(DEXA). All subjects were measured BMD at lumbar vertebrae and both femurs by DEXA. The balance function was evaluated by stork stand test(SST) and star excursion balance tests(SEBT). The pain of bone was tested with the pain assessment scale. the The changes of senile osteoporosis by oral calcium and active vitamin D, which is in BMD and balance function and the pain of bone before treatment and 6 month, 12 month after treatment, were compared. Correspondence analysises were conducted between age and BMD and balance function and between right femur BMD and balance function. All datas were shown by( x ±SD) and were analyzed using SPSS16.0.Results:1 BMD before treatment at lumbar vertebrae, left femur, right femur(0.65±0.17,0.54±0.08,0.51±0.11)(g/cm2)and 6 months after treatment in lumbar vertebrae, left femur, right femur(0.65±0.16,0.57±0.13,0.53±0.09)(g/cm2)were not statistically significant(P>0.05); but, BMD before treatment and 12 months after treatment at lumbar vertebrae, left femur, right femur(0.77±0.16, 0.62±0.09, 0.62±0.11)( g/cm2) were statistically significant(P<0.05).2 The balance function before treatment in SST(10.83±2.93s) and 6 months after treatment in SST(11.07±2.60s) was not statistically significant(P>0.05); The balance function before treatment in SST and after treatment at 12 months in SST(12.43±2.57s) was statistically significant(P<0.05).3 The balance function before treatment in SEBT in the east, southeast, south and southwest directions and 6 months after treatment in SEBT was not statistically significant(P>0.05); The balance function before treatment in SEBT and 12 months after treatment in SEBT was statistically significant(P<0.05).But, The balance function before and after treatment in SEBT in the north, northeast, west and northwest directions was not statistically significant(P>0.05)4 The pain of bone before and after treatment was not statistically significant(P>0.05).5 The results indicated that the age was negatively correlated with BMD at lumbar and both femur by liner correlaton analysis(r=-0.371,P=0.000;r=-0.430,P=0.000;r=-0.426,P=0.000). However, there was no correlation between the age and SST, SEBT with liner correlaton analysis. In addition, the results indicated that the right femur BMD was positively correlated with SST and SEBT in east, southeast and south directions by liner correlaton analysis(r=0.328,P=0.002;r=0.357,P=0.001;r=0.416,P=0.000).However, there was no correlation between age and SST, SEBT in north, northeast, southwest, west and northwest directions by liner correlaton analysis.Conclusions: Oral calcium and avtive vitamin D can improve the BMD, the balance function of the old patients with senile osteoporosis; however, it is not obvious that oral calcium and vitamin D improve the pain of bone of the old patients. The enhancement in the balance function and the improvement in the BMD of the old patients can effectively reduce the fall risk and the fractures of the old patients with senile osteoporosis. The quality of life and the prognosis of the patients can be improved. And the financial burden of the social and family can be reduced. |
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