| Objective: By correlation and contrast the urinary iodine of normal adult and the preoperative patients of common clinical thyroid diseases, we explored the relationship between high incidence of thyroid diseases and high levels of iodine intake, we want to provide a theoretical basis for preventing and treating thyroid diseases by individual adjustment to reach the appropriate level of iodine intake.Methods: In this study, we collected the preoperative fasting urine of patients with thyroid surgery in the department of pathology in the Second Hospital of Hebei Medical University from February 2014 to June 2014. We selected 322 patients with thyroid tumors,and the removal of tissue had pathology results after operation. The study including 198 cases of nodular goiter, 62 cases of thyroid papillary carcinoma, 26 cases of primary hyperthyroidism, 16 cases of Hashimoto’s thyroiditis, thyroid adenoma 20 cases, and the other to collect normal adults fasting urine 255 cases in the same period in Hebei Medical University Second hospital Physical examination center for medical examination as the control group, all urine iodine content was measured by Ammonium persulfate digestion arsenic cerium catalytic spectrophotometry. All aspects of the statistics were analyzed by SPSS21.0 statistical software, all data were compared by using Mann-Whitney U test and the Kruskal-Wallis H test, test criterion for P<0.05 was statistically significant.Results: We used statistical software for data analysis to obtain the results of normal adult and various patients with thyroid disease median urinary iodine(MUI) and the mean ± standard deviation. 198 cases of nodular goiter median urinary iodine(MUI) was 238.70μg/L, mean±standard deviation( X ±S) was 283.46 ± 196.89μg/L, 62 cases of thyroid papillary carcinoma median urinary iodine(MUI) was 246.00μg / L, mean ± standard deviation( X ±S) was 285.05 ± 178.54μg / L, 26 cases of primary hyperthyroidism median urinary iodine(MUI) was 85.05μg / L, mean ± standard deviation( X ±S) was 141.15 ± 182.79μg / L, 16 cases of Hashimoto’s thyroiditis median urinary iodine(MUI) was 398.70μg / L, mean ± standard deviation( X ±S) was 412.95 ± 173.42μg / L, 20 cases of thyroid adenoma median urinary iodine(MUI) was 85.05μg / L, mean ± standard deviation( X ±S) was 128.70 ± 180.55μg / L. 255 cases of normal adult median urinary iodine(MUI) was 188.50μg / L, mean ± standard deviation( X ±S) was 240.39 ± 193.49μg / L. We used Kruskal-Wallis H test, to compare the above data, the results were statistically significant, indicating that urinary iodine levels of the 6 groups, which included patient group and the normal adult group were different. Further application of Mann-Whitney U test for the median urinary iodine(MUI) and the mean ± standard deviation between 5 patients group with the normal adult group to make pairwise comparision, in addition to the median urinary iodine(MUI) and mean ± standard deviation in patients with thyroid adenoma group showed no significant difference compared with the normal adult, there were significant differences among the remaining cases and normal adults, it can be considered that the urinary iodine levels of nodular goiter, thyroid papillary carcinoma and Hashimoto’s thyroiditis patients were higher than normal adults, and the urinary iodine levels of primary hypothyroidism patients were lower than the normal adult, no significant differences in the level of urinary iodine in patients with thyroid adenoma and normal level.The urine iodine is divided into <100 g/L, 100~199.99 mu g/L, 200~299.99 g/L, more than 300 g/L four level, further analysis of the various levels of the frequency distribution of the patients in each group, through the Kruskal-Wallis H test we found that in all groups of patients of thyroid disease and normal adult urine iodine frequency distributions were significantly different, and the difference was statistically significant. We continued to apply the Mann-Whitney U test for 5 groups data sets and normal adult pairwise comparison respectively, the results were statistically. The Constituent ratio of nodular goiter, thyroid papillary carcinoma and Hashimoto’s thyroiditis patients with urinary iodine ≥300μg/L were significantly higher than normal, the proportion of rest of the urinary iodine levels were lower than normal corresponding proportion, Primary hyper- thyroidism patients with urinary iodine <100 mu g/L proportion was more than that in the normal, the rest of the urinary iodine level of patients was lower than normal proportion, the urinary iodine of thyroid adenoma ≥300μg / L and <100μg / L ratio were higher than normal percentage who, in the middle of urinary iodine levels were lower than normal constituent ratio. Conclusion:1 Patients with abnormal urinary iodine thyroid disease, nodular goiter, thyroid papillary carcinoma, Hashimoto’s thyroiditis patients with urinary iodine levels higher than normal, primary hyperthyroidism patients’ urinary iodine levels lower than normal, urinary iodine level in patients with thyroid adenoma showed the percentage of higher and lower levels urinary iodine was higher than the normal.2 The coexistence of high iodine and low iodine in patients with thyroid diseases, not blindly emphasized iodine or iodine intake restriction.3 Determination of urinary iodine can be used as a routine clinical examination, it plays a guiding role in iodine uptake scientifically and individualized for the healthy people and patients with thyroid disease, further to achieve the purpose of prevention and treatment thyroid and other diseases caused by abnormal thyroid iodine uptake. |
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