Analyze Clinicopathologic Featues And Prognosis Of Borderline Overian Tumor

Objective:To analyse the clinicopathological characteristics, prognosis and recurrence of borderline ovarian tumor(BOT). To study the factors influencing the relapse and prognosis of BOTMethods:Various clinicopathologic factors of 89 patients with borderline ovarian tumors admitted to the Fourth Hospital of Hebei Medical University between February 2003 and September 2009 were reviewed. The effects of clinicopathological characteristics upon recurrence and fertilty outcomes were analyzed by SPSS19.0.Results:The patients’ average age was 44.09±14.48 years old.The percents of elevated level on preoperative serum CA125 and CA199 were 55.74%(34/61)and 28.40%(23/81)respectively. 58 cases(65.17%) having received radical surgery while 31(34.83%) patients having received conservative surgery included 6 cases with unilateral or bilateral ovarian cystectomy and 25 cases with unilateral oophorectomy. 14 cases underwent comprehensive surgical staging.There were 8 patients operated by the way of laparoscopic surgery. 44 patients had postoperative adjuvant chemotherapy, the regimens of which were mainly a platinum-based intravenous chemotherapy. Mean size of the tumors was 16.16±9.96 cm. Serous(44.94%) and mucinous(44.94%) tumors were dominant histological types of BOT. SBOT’s mean size was 10.84±5.77 cm, while MBOT’s was 22.03±10.80 cm. 72 cases were limited to unilateral ovary. Among 89 patients, there were 68 cases in Stage Ia, 12 cases in Ib, 3 cases in II and 6 cases in III respectively. Mean duration for follow-up was 93.07 ± 26.18 months. As far no tumor-related death was reported,but 6 patients(6.74%) had recurrence. There were no effect on recurrent rate whether comprehensive staging surgery or not, serum CA125 and CA199 level elevated or not,either radical surgery. 31 patients having received fertility-sparing surgery and after operation 7 of them succeeded in pregnancy. The pregnancy rates of the two ways for conservative surgery were not significantly different.(P > 0.05).Conclusion:Majority of BOT have favorable prognosis,diagnosed young and in early stage. Most of the cases was limited to unilateral ovary. Canceration is also not directly related to recurrence.CA199 can be used as indicators of preoperative prediction and monitoring recurrence for BOT. FIGO stage,the size of tumor and histological types are not associated with recurrence. Whether comprehensive staging surgery or not does not affect the recurrence rate for BOT, and the majority pathologic type of recurrent tumors is still BOT. The surgical method and whether adjuvant chemotherapy or not does not affect the BOT recurrence rate.The pregnancy rates of the 2 ways for conservative surgery were not significantly different. The conservative surgery should be considered for young women who desire preservation of fertility and the size of tumors less than 10 cm, and careful follow-up is needed to detect recurrent disease in these patients.