| Objective: To study the clinical application of hepatic artery embolism chemotherapy combined with intratumoral injection of absolute ethanol lipiodol emulsion in treatment of large hepatocellular carcinoma, Comparative analysis of the in relieving clinical symptoms, Reducing the AFP index, Prolong the survival time and other advantages. Methods: 86 cases of primary liver cancer patients, and divided into control group(42 cases) and treatment group(44 cases), The control group using a simple hepatic artery chemotherapy and embolization in the treatment of chemotherapy with carboplatin, 0.2g, mitomycin 10 mg, Select 10-20 mg 5-20 ml and adriamycin lipiodol emulsion embolization mixing; Treatment group were treated with hepatic artery embolism chemotherapy combined with intratumoral injection of absolute ethanol lipiodol emulsion in the treatment of 2:1, Ethanol and lipiodol emulsion with ethanol lipiodol emulsion, Respectively after operation in 1 months, 3 months, 6 months, 12 months follow-up review, review of mass AFP, liver function index, blood and abdominal CT, and statistics of two groups of patients in the clinical treatment of the reaction, The decline rate of AFP, Progression free survival, 1 year survival rate of several aspects of the difference, and carries on the contrast analysis. Results: 1 Cases in treatment group, CR+PR38 reaction, effective rate was86.4%; control group CR+PR27 patients in clinical response, effective rate was 64.2%, two groups have significant differences, with statistical significance(P<0.05). The content of AFP in serum of two groups of patients was 2, Significantly reduced after treatment, tumor volume was significantly reduced, but the treatment group AFP decline rate and tumor size were significantly higher than that in the control group, The difference was statistically significant(P<0.05). 3, The control group and the treatment group the average progression free survival was 5 months, 7 months, The PFS was significantly prolonged, there was significant difference between the two groups statistical comparison, With statistical significance(P<0.05). The two group at 3 months, 6 months and 12 months survival rate have obvious difference, The treatment group were 96.3%, 81.5% and 33.2%, The control group were 91%, 66.1% and 20.2%. There was significant difference between the two groups in the 6 and 12 months cumulative survival rate(P<0.05). Conclusion: 1,Hepatic arterial chemoembolization, can reduce the tumor to obtain two surgical operation treatment, But only for the low cure rate, high recurrence rate. In 2, Hepatic artery embolism chemotherapy combined with intratumoral injection of ethanol and lipiodol emulsion in treatment of large hepatocellular carcinoma in the clinical response to treatment, the rate of decline in AFP, The tumor response rate and progression free survival, the survival rate was better than the simple TACE treatment or PELI treatment. |
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