| Objective: To observe the curative effect of the spleen and kidney deficiency syndrome(SAKDS), the improvement to the clinic symptoms, the reducing of urine trace albumin excretion rate(UAER), the intervention effect to hs-CRP, hcy and Cys-c when the kidney-Qi-nourishing therapy(KQNT) therapying early diabetic nephropathy(EDN).Methods: 60 cases of patients of EDN that TCM is Spleen and Kidney Qi Deficiency) are randomly divided into treatment group and control group and each group are 30 patients. The patients of control group are conducted control of blood pressure, blood glucose and other symptomatic therapy. And on these basis the patients of treatment group are given KQNT treatment, 3 months for a course. The urinary microalbuminuria(m Alb), 24 h urinary albumin excretion rate UAER, FBG, m Alb/C,hs-CRP, Hcy and Cys-C are detected and treated with statistics before and after treatment. TCM syndrome score are evaluated.Results:(1) The total effective rate of clinical effect in the treatment group was 86.67%, which was better than that in the control group 63.30%, the difference was significant(P<0.05).(2) TCM syndrome score were compared:After treatment, patients were symptom score has declined. TCM syndrome score in the treatment group compared with the control group were significantly decreased, the difference was statistically significant(P <0.05). Prompt treatment group reduced symptom scores than the control group.(3)Symptoms compare the efficacy of distribution: After 3 months of treatment, the efficacy of the distribution of the main symptoms of the two groups was statistically significant(P<0.05). The main symptoms of the efficacy of prompt treatment group than the control group.(4)m Alb, UAER comparison: two groups of patients in March after m Alb, UAER have declined. Treatment compared with before treatment group within 3 months: two groups of patients m Alb, UAER decreased than before treatment(P <0.05), but the treatment group decreased significantly more than the control group(P <0.01).(5)After treatment, the two groups have encountered a certain extent reduce Scr, BUN, but not statistically significant.(6)FPG, 2h PG comparison: before treatment FPG, 2h PG no significant difference(P> 0.05); there was no significant difference between before and after treatment difference(P> 0.05). Description two consistent blood sugar lowering effect.(7)Urinary albumin / creatinine ratio(MALB / C) comparison: the treatment group MALB / C decreased significantly compared with the control group, the difference was statistically significant(P<0.05). Prompt treatment group reduced MALB / C than the control group.(8)Serum hs-CRP, Hcy, Cys-C levels of comparison: After treatment, serum hs-CRP, Hcy, Cys-C levels decreased significantly compared with the control group, the difference was statistically significant(P<0.05). Prompt treatment group decreased serum hs-CRP, Hcy, Cys-C levels than the control group.Conclusion: Yiqibushen method can reduce the early stage of diabetic nephropathy in patients with spleen qi deficiency syndrome urinary albumin excretion rate(UAER) and 24-hour urinary protein excretion trace(m Alb), urinary albumin / creatinine ratio(m Alb / C), reduce hs-CRP, Hcy, Cys-C, improve diabetic nephropathy in patients with kidney, spleen and kidney qi deficiency syndrome micro-inflammatory state, thereby improving clinical symptoms. Kidney Qi method for early diabetic nephropathy spleen qi deficiency syndrome have some intervention. |
