| ObjectivesTo investigate the cognitive status quo of OP elderly people in Jinan. Through one-year collagen peptide diet intervention on community elderly, evaluate the adjustment of dietary structure, behavior and analyze its effects on bone mineral density T value, bone turnover biochemical indicators. And then we analyzed the nutrition knowledge, attitude and behavior of OP group and control group. Thus, for sake of elderly we studied, a reference was provided for the design of bone health management and a theoretical basis was provide for patient’s health promotion program and the implementation of disease prevention measures.MethodsFrom September 2013 to December 2014, we recruited 369 type among middle-aged and elderly population in 5 administrative regions of Jinan City, of which 366 valid samples. All study objects come from Health Screening Center of Second Affiliates Hospital of Shandong University of Traditional Chinese Medicine. We implemented a one year collagen peptide dietary behavior intervention on inclusion in the study, consisting of making them have specific collagen peptide intake, health education on three meals a day diet and bone health, adjusting intervention scheme and intensity according to personal condition. After intervention, study objects including 74 males,131 females (postmenopausal), and 82 OP patients (OP group),123 non-OP samples (control group). All study objects were in 49 to 88 age range, the average age was (69.23±7.65), the average age of male was (71.80±7.22), female was(68.30±6.84). Questionnaire(includes basic information, patients’knowledge, attitude and behavior about bone health, medical history, family history, sports, menstrual history and so on), physical measurements and biochemical parameters of bone turnover(includes parathyroid hormone (PTH), serum alkaline phosphatase (ALP), serum calcium (Ca) and serum phosphorus (P)) and dietary survey were carried out before and after the intervention respectively. After the intervention, we analyzed and evaluated the questionnaire survey, physical measurements and biochemical parameters.Object of study to meet the requirements of normal mind, verbal fluency, clear consciousness, normal behavior; informed consent. Exclusion criteria:acute and chronic hepatitis, kidney disease and endocrine disorders, history of anti-osteoporosis drug, hormone, diuretics and so on.Results1. The mean of BMI was (24.97±2.95) kg/m2 in the early intervention, higher than the normal range, the prevalence of overweight and obesity were 46.8% and 15.6% respectively. BMI of female higher than male, but the difference was not significantly(P>0.05). The BMI among the fore age groups did not differ significantly(P>0.05),and the maximum was 60 to 70 age group.2. OP detection rate of female was 53.4%, higher than male 35.1%. difference was significantly(χ2=6.360, P<0.01). BMD T-score was (-2.47±1.37)g/cm2, in range of osteopenia, and female far less than male(P<0.01), With the increase of age, T-score ended to increase, and among the group, within-group differences were statistically significant (P<0.05). T values increased with elevated BMI has a significant difference in the trend group(P<0.01), between normal and overweight group difference was not statistically significant, the differences between the other groups were statistically significant (P<0.05).3. Serum Ca, P, ALP, PTH mean value of study object were within the normal range, Gender difference of serum calcium, phosphorus, ALP mean were significantly, and higher for females(P<0.05).With the increase of age, the level of serum Ca tended to increase and serum P tend to decrease, differences within the group were significantly (P<0.05). With the increase of age, the level of PTH tended to increase and ALP tend to decrease, differences within the group were not significantly.4. Serum Ca and PTH level differences between OP group and control group were not significant. Group difference of serum P, ALP mean were significantly(P<0.05), and higher for OP group(P<0.05).5. The BMD T-score and ALP Spearman bivariate correlation analysis of OP group showed that there was a significant negative correlation between them(P<0.05). The BMD T-score and serum P Spearman bivariate correlation analysis of control group showed that there was a significant negative correlation between them(P<0.01).6. Osteoporosis nutrition knowledge mean score of male was higher than that of female, and control group was higher than OP group, before and after intervention. but the difference was not significantly(P>0.05). After the intervention average score of objects of study was higher than the before(P<0.01). The title that correct answer rate more than 80% accounted for 60% of the total subject. After intervention, the . correct answer rate of the subjects that " main lack of elements in OP ", " most appropriate method of prevention of bone and joint diseases ", "the gold standard for detection of OP" were significantly increased(P<0.05). The correct answer rate of the subjects that "which gender was easier to suffer from OP" was increase and "are OP can cause fractures" was decrease, the difference was not statistically significant.7. Average score of diet habits of female was higher than male, and that of control group higher than OP group, but the difference was not significantly. After the intervention, the average score of diet habits of study objects was higher than the before(P<0.05), and answer status of "Diet taste", "dairy intake", "sesame and sesame products intake", "insisted the combination of diet and exercise lifestyle" were obviously better than before(P<0.05), After the intervention, the answers of "seafood intake", "soy and soy intake", "drinking coffee situation", "alcohol consumption", "outdoor movement" were better than before, but the differences was not statistically significant(P<0.01).8. After the intervention, felling of "joint and muscle pain, swelling condition" turned into better significantly, "joint flexibility" elevated, phenomena of joint stiffness, difficult movement was in reducing, the differences were significant. "Condition of bone pain" was improved(P>0.05), and "degree of pain sensation" was significantly lower than before. After the intervention, feeling of mood and skin changed for the better, the differences was not statistically significant. After the intervention, study subjects feel stairs easy, cramps symptoms reduced, age spots turns lighten, the differences were significant(P<0.05).9. After the study intervention, BMD T-score, serum Ca,, PTH increased slightly, BMI, serum P values decreased, BMD T-score and serum Ca among the intervention differ significantly(P<0.05). After the intervention, among males, level of BMD T-score have a tendency to rise, serum Ca increased significantly(P<0.05), serum PTH have a tendency to declined, serum ALP decreased significantly(P<0.01). Among females, level of BMD T-score, serum Ca tend to rise, and BMD T-score changed significantly (P<0.01), serum ALP, PTH was significantly decreased (P<0.05).Conclusions1. The knowledge of bone nutrition of elderly subjects was not comprehensive, and daily dietary habit is not healthy. The mastery of knowledge and living behavior of health of OP group were worse. There was significant negative correlation between BMD T-score and serum ALP in OP group, and significant positive correlation between BMD T-score and serum P in control group.2. After dietary intervention based on collagen peptide in elderly, the level of bone health related knowledge, attitude, behavior has been improved, even though part of the increase was limited.3. Dietary intervention based on collagen peptide has an obvious effect on biochemical turnover markers of bone and physical index in study subjects, especially OP group. The detection rate of bone loss increased, the OP detection rate reduced. With the increase bone density value, serum Ca, calcium to phosphorus ratio, PTH increased, serum ALP decreased significantly.4. The intervention has an obvious effect on dietary habits, such as the increased intakes of milk, sesame, seafood, soy products, Quality of life was significantly improved. But the accuracy impact on the specific dietary nutrients also need to explore, improved and perfected through the process of future interventions. |
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