Analysis Of Vascular Dementia And Serum Uric Acid Level

Objective:Vascular dementia(Va D) is a kind of dementia type higher incidence rate in our country. In senile dementia incidence, just below the Alzheimer disease(AD). The basis of disease in the pathogenesis of Va D are cerebrovascular disease, when lesions affect senior functional zone associated with cognitive function, it may lead to cognitive impairment, gradually or rapidly dementia. Va D annual incidence for 5-9/1000 people. One of the patients with vascular dementia can be accounted for the total number of about 1/5 at the same time suffering from dementia; Alzheimer disease and vascular dementia(Va D) can account for 1/10 to 1/5. Once suffering from vascular dementia will give the society and the family a heavy burden, but also his patients quality of life will be decreased. Although modern medical level has achieved a make a spurt of progress of development, to overcome the difficult miscellaneous diseases also gained the success that attract worldwide attention, but there are still incurable disease exist, such as vascular dementia once diagnosed, at present there is no cure, only stay in treatment, cognitive function in improving or delaying symptoms therefore, understanding and prevention of vascular dementia(Va D the occurrence of imminent). Through the joint efforts of medical persons and patients, for diabetes, hyperlipidemia, hypertension, smoking, alcohol has been recognized as the control of risk factors for stroke and cognitive impairment, has made gratifying achievements. But the serum uric acid level and whether the occurrence of vascular dementia, the development of correlation is inconclusive, so how to evaluate the effects of level of serum uric acid on vascular dementia caused no start.Uric acid(SUA) is the body The new supersedes the old. process, oxidation decomposition products of nucleic acid, is a kind of purine, most excreted via the kidneys. 80% of the uric acid is a nucleic acid in the body of old and new cells in the catabolism of catabolism produced; the remaining 20% comes mainly from animal foods containing purine rich foods and the intake of. Uric acid produced by the body’s way: most of the renal metabolism and ultimately with the urine, a small part of the intestine with the feces. The close relationship between hyperuricemia and gout are well known, not only such, coronary heart disease, diabetes, hypertension, kidney disease often occurs in patients with hyperuricemia, and we have been clear: coronary heart disease, diabetes, hypertension and vascular dementia has a dangerous relationship, absolutely so, tell from some kind of meaning of serum uric acid levels increased with the vascular dementia should be indirect relations. In recent years, diagnostic test for serum uric acid assay as kidney disease, gout and heart, cerebrovascular disease risk factor screening and prognosis evaluation of clinicians, caused more and more attention. While hypouricemia in previous research, is often ignored, as a kind of reducing substances in the body, which play a decisive role in the redox reactions play a role is gradually being re understanding, in recent years researchers have an important discovery: uric acid because of its reduction, plays an important role in oxidative stress the reaction, resulting in a protective effect on nerve cells, while the others think it accelerated oxidation reduction reaction of uric acid, can produce a large number of free radicals cause damage to nerve cells. The level of vascular dementia and the serum levels of uric acid(Va D) correlation is the focus of this paper, through discussing the difference of vascular dementia(Va D) patients and normal elderly blood uric acid level, and clinical significance of serum uric acid level, observe whether the risk factors of Va D, in order to provide new ideas for the prevention and treatment of Va D.Methods:From 2014 January to 2014 July in the second hospital of Hebei Medical University hospital or outpatient department of internal medicine. Inclusion criteria: male or female, age 55 years old of above, no obvious kidney disease, heart disease, liver disease, the exclusion of central nervous system infection secondary to chronic alcoholic dementia, does not exist, the negative of the other organic brain lesions, head trauma, not suffering from mental diseases(such as mania, depression, etc.) the recent not taken hypolipidemic drugs and vitamins and drugs affecting lipid metabolism of patients. Vascular dementia(vascular dementia, Va D) diagnostic criteria: according to the 1993 Swiss Neuroscience Research International Association and the USA National Institute of neurological disease and Stroke Research Institute(NINDS / AIREN clinical criteria for the diagnosis of vascular dementia, CCDVD) formulation is likely diagnosis of vascular dementia(probable) standard, the clinical history, nervous system examination, brain CT scan by a specialist diagnosis. Patients diagnosed with Va D, as the case group, 72 cases in total, and by using mini mental state examination(MMSE) for dementia degree assessment; the same period age non dementia 70 cases of healthy people as control group. Determination of uric acid, homocysteine, triglyceride, low density lipoprotein cholesterol, fasting blood glucose levels were observed in the two groups, the changes in the levels of the above indexes, and processing the data using SPSS 13 statistical software, when statistically significant difference when P<0.05.Results: Compared with control group, vascular dementia group serum urea levels decreased, the difference was statistically significant(P<0.05), triglyceride, serum vascular dementia and low density lipoprotein cholesterol, homocysteine, blood sugar were increased, and the difference was statistically significant(P<0.05). Among them, the level of serum uric acid in patients with mild vascular dementia is higher than that of patients with moderate vascular dementia, and moderate vascular dementia patients serum uric acid level was higher than that of severe vascular dementia uric acid levels, the difference was statistically significant(P<0.05).Conclusion: In patients with vascular dementia exists to reduce serum uric acid level, elevated homocysteine, triglyceride, low density lipoprotein cholesterol, blood sugar level. The decrease of serum uric acid level may be a risk factor of vascular dementia, with the reduction of serum uric acid level in patients with vascular dementia, dementia degree is more and more heavy. Detection and intervention levels of uric acid may help to understand the severity in patients with vascular dementia, and has a guiding effect on the prevention and diagnosis and treatment.