A Meta-analysis Of Coffee Consumption And Hepatocellular Carcinoma

Objective:To assess the relationship between coffee consumption and risk of hepatocellular carcinoma.Methods:We searched the CBM、CKNI、Wanfang dataase、Pub Med、MEDLl NE、EMBASE、OVID、Cochrance, collect the case-control study and cohort study published before September 2014 and concerned about coffee consumption and hepatocellular carcinoma. Two evaluators independently reviewed and selected articles according to inclusion criteria and exclusion criteria. If necessary, contact the author to obtain futher information. Then, we extract the data and assessed the quality of the included literatures. State 12.0 was used to conduct meta-analysis.Results: A total of 16 studies involved, including 9 case-control study and 7 cohort study. Compared with the non/lowest coffee drinkers, coffee consumption was strongly associated with lower risk of hepatocellular carcinoma, the RR was 0.50, 95%CI(0.42-0.59), P=0.000 for coffee drinkers. Subgroup analyses indicated that the RR was 0.48, 95%CI(0.38-0.62), P=0.000 in cohort study group and the RR was 0.50, 95%CI(0.40-0.63), P=0.000 in case-control study and the RR was 0.45, 95%CI(0.36-0.56), P=0.000 in asian populations and the RR was 0.57, 95%CI(0.44-0.75),P=0.000 in european populations and the RR was 0.38 95%CI(0.25-0.56), P=0.000 in men and the RR was 0.60, 95%CI(0.33-1.10), P=0.097 in women. The RR was 0.35,95%CI(0.23-0.53), P=0.000 for heavy drinkers and the RR was 0.51, 95%CI(0.42-0.63), P=0.000 for moderate drinkers and the RR was 0.65, 95%CI(0.46-0.91), P=0.012 for low drinkers. In the group of patients suffered from HBV or HCV, the RR was 0.54, 95%CI(0.36-0.81), P=0.003. One more cups of coffee/day was associated with a 21% decreased risk of hepatocellular carcinoma, the RR was 0.79, 95%CI(0.70-0.89), P=0.000.Conclusion: The current epidemiologic evidence suggests an inverse association between coffee consumption and risk of hepatocellular carcinoma; there is a dose-response relationship between coffee consumption and the risk of hepatocellular carcinoma. Although coffee drinking may be an protective factor for hepatocellular carcinoma, but that still has some side effects on health.Whether to recommend drinking coffee for preventing hepatocellular carcinoma requires careful consideration.