Amplitude Of Low-frequency Oscillations In Blepharospasm:A Resting-state Functional Mri Study

Objective:Blepharospasm(BSP) is a focal dystonia disease characterized by involuntary blinking and eyelid spasms, Seriously affect the quality of life and social function.In order to investigate the pathogenesis of blepharospasm,the present study Compare the different brain functional activities between blepharospasm patients and normal controls by resting-state functional magnetic resonance imaging(f MRI)-fractional amplitude of low-frequency fluctuation(f ALFF).Methods:The study included 24 patients with BSP(8male, 16 female,mean age:49.58years),in whom the average duration of symptoms was 10.00 ± 3.82 months,and another 24 subjects from an age- and sex-matched control group(6male, 18 female,mean age:50.88 years).All the patients were given JRSS scale examination and SDS, SAS psychological test.resting-state f MRI was performed in both the patients with BSP and normal control. The radiological results were analyzed with software DPARSF、SPM8 and REST.Using the two sample T test to compare patients with blepharospasm group and healthy control group differences in brain f ALFF. By the SPSS17.0,we made the statistical analysis of the datas and research into the correlations of them.Results:Compared to the controls,blephrospasm showed significant f ALFF increased in left postcentral gyrus,bilateral supplementary motor area,left cerebellum anterior lobe as well as decreased f ALFF in bilateral superior medial frontal gyrus,bilateral cingulum,right angular gyrus,bilateral precuneus..But there was no correlation between the f ALFF with the average duration of symptoms and SDS and SAS score.Conclusion:Abnormal sensation and the supplementary motor area(including cerebral postcentral gyrus between sensory areas and supplementary motor area and the relationship between abnormal loop) and cerebellum, the default network are directly or indirectly involved in the pathogenesis of blepharospasm,.there was no correlation between the BSP patients’ s f ALFF with the average duration of symptoms.