| Objective: Childhood asthma as common respiratory disease in the world, touching painless, children asthma suppress is extremely painful.Mentor professor zhang jie found in the many years of clinical work, thinking many temper deficiency syndrome in children with asthma remission lung qi deficiency in the clip have phlegmy, low immunity, this proposed thrift ning xiao Chinese medicine prescriptions, and joint meridian therapy using convenient, suitable for children per cutem therapy treating children asthma remission has good curative effect, this topic validation thrift ning xiao free decoction combined cutem therapy on children asthma remission the curative effect of pulmonary spleen-deficiency type, by means of modern medicine to explore the role of traditional medicine in the prevention and treatment of childhood asthma and asthma prevention and treatment for children to seek a safe, effective treatment methods.Methods: Hebei province hospital pediatric clinic diagnosis of children with asthma remission of pulmonary spleen-deficiency type 60 cases.Single blind random divided into control group and treatment group, the number of cases are 30 cases, treatment group given regular low-dose glucocorticoids inhalation joint thrift ning xiao free decoction granules, and per cutem therapy.Control group given conventional small doses glucocorticoid inhaled and oral moder oral liquid treatment, the total treatment for 3 months, 3 months of follow-up, through the observation before and after treatment in children with asthma attack frequency of breathing, breathing duration and number of respiratory tract infection, clinical general curative effect, TCM symptoms and total integral single integral, peripheral eosinophil count and immunoglobulin IGA, IGG, such as data, using SPSS17.0 statistical software for statistical analysis, statistical description with mean + /- standard deviation according to measurement data, measurement data using T test, and repeat the design analysis of variance, count data using x2 test, using Mann-Whitney U rank of nonparametric test and inspection as rank statistics analysis method, the two groups P<0.05 for the difference, to evaluate the therapeutic effect of treatment group and control group.Results:1 Two groups after treatment, according to the clinical total curative effect in treatment group cases clinical control 7 cases, 15 cases were markedly effective, effective cases in 7 cases, 1 cases ineffective cases; Control group clinical control cases in 3 cases, 9 cases were markedly effective, effective cases in 16 cases, ineffective cases in 2 cases. Two independent sample rank and inspection(the Mann-Whitney U test), Z=2.497, P=0.013. Results the two groups was statistically difference, the effect of the treatment group than the control group.2 Compared the two groups before and after the treatment of children with total score of syndromes and syndrome integral, the repetitive measure analysis of variance showed that there are differences before and after treatment the effect(P<0.001), syndrome after treatment to reduce; Before and after treatment in treatment group and control group comparison between the two groups differ(P<0.05), and before and after treatment are interaction effect(P<0.05), the treatment group improved in various syndromes is better than that in control group.3 Compared the two groups before and after the treatment with peripheral eosinophil count: the repetitive measure analysis of variance showed that contrast no statistical difference between the two groups before and after the treatment(P>0.05), before and after the two groups of measuring and processing there is no interaction effect(P>0.05).4 Compared the two groups before and after the treatment with Ig A, Ig G, after repeated measurements analysis of variance, the main effect of Ig A, Ig G have difference before and after the treatment(P<0.001), Ig A, Ig G rise; Treatment group and control group Ig A has main effect difference(P=0.000), Ig G main effect difference(P=0.238); Interaction effect measurement before and after and processing(P=0.028), degree of Ig A, Ig G, control group rose higher than the treatment group.5 Contrast before and after treatment of two groups of children with seizures indicators: the variance analysis of repeated measurement, before and after treatment with wheezing episodes, number of infections, attacks the main effect of time have difference(P<0.001), two groups of treatment are effective; Measuring and processing before and after interaction effect(P<0.05), the treatment group is better than the control group.Conclusion: thrift ning xiao decoction granules with free per cutem treating children asthma remission lung spleen-deficiency type in children with clinical curative effect, control attack frequency of breathing, breathing attacks, duration, number of respiratory infections in children with the treatment of TCM syndrome total integral action is better than that of control group. |
