Research Of The Correlation Between Serum FIB With The Acute Coronary Syndrome And Its Risk Of Severe Degree

Objective:Acute coronary syndrome has different clinical manifestation and its mortality rate was high. Severity of coronary artery stenosis was not the same and hemodynamic changes was a huge difference.There were obvious differences in the prognosis with acute coronary syndrome. Serum FIB has been confirmed as a predictor of cardiovascular events. The purpose of this study was to explore the correlation between serum fibrinogen with the presence and the severity of patients with acute coronary syndrome.Methods:A total of 692 patients with acute coronary syndrome who made a definite diagnosis were selected. Ninety-nine patients without coronary artery stenosis severed as control group. Detail informations were record including age, gender, history of alcoholic, smoking, hypertension, diabetes. All patients were detected FIB and some other biochemical indicators levels. All of them were screened by coronary angiography and electrocardiogram. Using the gensini scores evaluate the severity of coronary artery disease. The Severity of the acute coronary syndrome was evaluated by the global registry of acute cornary event (grace) scores. The relationship betwwen involvement of coronary lesion count, acute coronary syndrome types, gensini score, grace scores and level of serum FIB was analyzed to clarify the correlation between FIB with acute coronary syndrome process, severity of the acute coronary syndrome and stenosis of coronary arteries.Results:1. The serum FIB levels were obviously higher in the STEMI group patients than NST-ACS group and control group.However, the serum FIB levels were also significantly higher in patients with NST-ACS than control group.2. The serum FIB levels significantly ascended as the involvement of coronary vessels increased.3. Patients in higher gensini score had higher serum FIB.With the increase of gensini score, the levels of FIB was ceaseless aspiring.4. As the rising of grace score, the levels of FIB was significantly increased and the differences were statistically significant.5. The correlation analysis showed that grace scores and gensini score had a positive correlation with serum FIB in ACS patients.6. Moreover, the serum FIB were independently correlated with the grace score in a multivariate logistic regression model.7. The areas under the ROC curve of serum FIB in diagnosis of acute coronary syndrome are 0.876, suggest that the serum FIB has a higher predictive of ACS. A 4.15g/L cut-off value of FIB predictd the presence of ACS with a sensitivity and specificity of 80.1 and 79.9.Conclusion:1. The level of serum FIB can reflect the severity of acute coronary syndrome and stenosis of coronary arteries.2. The serum FIB levels have close relation with the Acute coronary syndrome and serve as a independent risk factors for the severity of the acute coronary syndrome 3. The serum FIB can be devoted to predict the risk of the Acute coronary syndrome.4. Combination of serum FIB levels may have the important clinical value on early risk stratification evaluation of prognosis and treatment options.