Diagnostic Value Of Analysison Adc Sindifferent Measuring Methods In Breast Lesion And The Subtypes Of Breast Cancer

Objectives To investigate the value of the differential diagnosis of benign and malignant breast lesions and invasive ductal carcinoma of different molecular typing MR apparent diffusion coefficient (ADC)Methods Collect invasive ductal carcinoma 278 cases,37 cases of benign breast disease, according to the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) of the chemical test results immunohistochemistry the patients in our hospital 278 cases of invasive ductal carcinoma were divided into luminal A, luminal B1, luminal B2, HER-2 (+) and triple negative type 5 kinds of typing, measuring lesion on DWI image shows the apparent diffusion coefficient (ADC) values. Determine the diagnostic threshold ADC value by ROC curve, and thus the value of the differential diagnosis, while ROC calculate the area under the curve for each type of ADC values were analyzed using statistical software SPSS 16.0.Results 1. ADC values of benign and malignant breast lesions analysis. By KS normality test to determine the invasive ductal carcinoma and benign lesions ADC values are normally distributed, ADC values of benign and malignant lesions were 0.865±0.013,1.661±0.029, t-test shows p<0.05, benign and malignant lesions meaningful differences in ADC values.2. Benign and malignant breast lesions threshold.By ROC curve analysis,, take maximum Youden index as a standard to determine the optimal threshold ADC value 1.253×10-3 mm2/s, in order to determine the threshold value of benign and malignant lesions, with a sensitivity of 96.0% and a specificity of 97.3%, the area under the ROC curve was 0.987, indicating that the ADC value with high diagnostic performance.3. ADC value and invasive ductal carcinoma of the relationship between molecular typing.The mean ADC value of invasive ductal carcinoma of 0.865×10 mm2/s, the difference between invasive ductal carcinoma various molecular typing mean ADC values were statistically significant (F=4.000, P=0.004), pairwise comparisons 5 differences between molecular typing statistically significant (F=2.406, P=0.05). ADC value and invasive ductal carcinoma molecular typing a positive correlation (correlation coefficient=0.156, p=0.009).4. respectively, component type ADC values and ADC values of benign line ROC curve analysis for the determination of the largest area under the ROC curve Luminal A group,95% CI 0.972-1.000, indicating that the ADC values of invasive ductal carcinoma Luminal A type diagnosis highest performance, the threshold is 1.200 × 10-3 mm2/s, with a sensitivity of 98.2% and a specificity of 97.3%.Conclusion 1.the difference between benign and malignant breast lesions ADC values of benign and malignant lesions meaningful, benign and malignant lesions of the threshold 1.253 × 10-3 mm2/s;2. ADC value with invasive ductal carcinoma molecular typing a positive correlation, the highest for invasive ductal carcinoma molecular subtypes Luminal A type diagnosis performance.