Application Of Apparent Diffusion Coefficient In The Process Of Chemoradiotherapy For Esophageal Carcinoma

Objectives:To explore the value of apparent diffusion coefficient values in the evaluation of Chemoradiotherapy efficacy for esophageal cancer.Methods:This study prospectively enrolled 54 patients with esophageal cancer who were diagnosed by biopsy and were treated with Chemoradiotherapy(CRT).Magnetic resonance examination was performed at four time points,before treatment,concurrent chemoradiotherapy for the 10th,20th,and after treatment.The length and thickness of the lesion were measured using magnetic resonance T2-weighted imaging,and the ADC values of the target lesion were measured using an ADC map.The patients after the end of chemoradiotherapy were divided into the remission group(CR and PR)and the non-remission group(SD and PD)according to the evaluation criteria in solid tumours Response evaluation criteria 1.1(RECIST 1.1),and then analyzed by SPSS software.The dynamic changes of ADC value,length and thickness of the target lesion at the time point were compared,and compare the rate of change for this three groups between the remission group and the non-remission group.Results:The ADC,length and thickness of the lesions were statistically significant(p<0.05)at four time points during treatment.and the ADC value showed a linear upward trend with the extension of time.The length and thickness of the lesion showed a linear decline with time.and the absolute value of the change rate of the ADC value in each time period was higher than the length and thickness of the target lesion.The rate of change between the 10th to 20th Chemoradiotherapy was the highest.The length,thickness and ADC values of the target lesions in the remission group and the non-remission group were tested at four time points.The t-test showed that the ADC before the treatment,the concurrent radiotherapy and chemotherapy,the 10th radiotherapy,and the end of the Chemoradiotherapy treatment.The p-values of the difference test in the remission and non-remission groups were 0.009,0.047,and 0.006(<0.05),respectively,and the difference was statistically significant.Conclusions:Synchronous chemoradiotherapy has a positive effect on the treatment of advanced esophageal cancer.After treatment,the length and thickness of the lesion are reduced,and the ADC value is increased.during chemoradiotherapy,Compared with the length and thickness,the ADC value can be earlier and more sensitive to confirm the reaction of tumor cells by Changes at the molecular level,and help to assist clinicians in the adjustment of radiotherapy doses in the early stages of treatment,ecome potential reference indicators to develop personalized treatment strategies for patients.before treatment,at the 10th of Chemoradiotherapy,after Chemoradiotherapy,ADC can be used to evaluate the efficacy of Chemoradiotherapy in patients with esophageal cancer;the best image acquisition time for the evaluation of radiotherapy and chemotherapy in patients with esophageal cancer using ADC values is between the 10th to 20th Chemoradiotherapy.