Assessment Of The Value Of DNA Image Cytometry In Cervical Lymph Nodes Fine Needle Aspiration And Serous Cavity Effusion

Objective: The aim of this study was to compare the value of DNA image cytometry against conventional smears in lymph nodes fine needle aspiration and serous cavity effusion.Materials and Methods: We reviewed a total of 550 patients(258 men and 292women; median age, 58.5 years; range, 16 years to 85 years) presenting with cervical lymph nodes lesions and serous cavity effusion between March 2013 and February2014 October.All of these patients used both CS and DNA-ICM method. Both of their diagnostic sensitivity, specificity and accuracy were calculated.Results: Sensitivity, specificity and accuracy of CS in lymph nodes fine needle aspiration were 90%、98.4% and 95.2%, respectively, whereas sensitivity, specificity and accuracy of DNA-ICM at 95%,100% and 98.1%. The Chi-squared test showed no significant performance differences between the two methods. Sensitivity,specificity and accuracy of CS in serous cavity effusion were 82.8%, 93.7% and83.0%, respectively, whereas sensitivity, specificity and accuracy of DNA-ICM at88.1%,100% and 94.7%.Chi-squared test used for showed a significant difference both of accuracy and specificity.Conclusions: The results of our study suggest that DNA-ICM has more advantagesover CS in serous cavity effusion. However, has no advantages in cervical lymph nodes.