Cerebral Cortical Diffusion-weighted Imaging In Type 2 Diabetic Patients With Retinopathy

ObjectiveTo detect whether there is any change of apparent diffusion coefficients (ADC) levels in different sites of the brain, particularly in areas associated with the memory,the emotion and the vision, in type 2 diabetic patients with retinopathy by measuring diffusion-weighted imaging (DWI).Materials and methodsWe selected 40 patients with type 2 diabetes in the first hospital of lanzhou university in August 2013 to September 2014, we collected 20 cases of nonproliferative diabetic retinopathy (group A) and 20 patients with proliferative diabetic retinopathy (group B) and 20 healthy control subjects (group C) to assess the effect of diabetes in itself. In group A,12 cases were male and 8 cases were females, ranging from 50 to 63 years, with an average age of 52.6+5.2 years, the disease course ranged from 4 to 15 years, median 10 years; in group B,11 cases were male and 9 cases were females, ranging from 42 to 60 years, with an average age of 53.7+7.7 years, the disease course ranged from 3 to 11 years, median 7 years; In group C,10 cases were male and 10 cases were female, ranging from 42 to 66 years, with an average age of 50.9+9.7 years. MR 1.5T routine and DWI scan were performed for three groups of research object, ADC values of midfrontal gyrus, superior temporal gyrus and cuneate gyrus were obtained.Every object record age, gender, duration, height and weight on an empty stomach and the glycosylated hemoglobin levels.This experimental design approved by the hospital medical ethics committee and all the objects signed informed consent.Using SPSS 19.0 software, measurement datas between groups were compared using analysis of variance, count data using chi square test. Correlation between variables was analyzed by Pearson correlation. P<0.05 was statistically significant.Results1.There is no significant difference in routine Tl or T2 weighted imaging between the three group.The ADC values of bilateral midfrontal gyrus and superior temporal gyrus cortex significantly increased in groups A and B compared to groups C (p< 0.005).2. The cerebral cortex ADC values of the bilateral midfrontal gyrus and superior temporal gyrus of three groups decrease in turn.3.The duration of disease positively correlated with ADC values of the right midfrontal gyrus in group A and B (r=0.37,p< 0.005).Conclusions1.Using functional magnetic resonance imaging (MRI) we can detecte the change of ADC values of cerebral cortex in diabetic patients, the activity of local cerebral cortex metabolism may decrease, proved that there is a definite relation between brain injury and type 2 diabetes, it also confirmed that DWI can as an effective method for diabetic patients with brain lesions;2.Patients with hyperplastic retinopathy of ADC values in the brain is relatively simple retinopathy patients is high, This result supports the association between diabetic retinopathy and brain injury,and with the progression of disease,the brain injury may be further aggravation..