Predicting Value Of Preoperative PLR And NLR On Recurrence-free Survival In Patients With Thyroid Papillary Carcinoma

Objective:To evaluate whether platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio(NLR) predicts risk of recurrence in patients with papillary thyroid carcinoma.Methods:A retrospective study was performed to analyze the clinical data of 135 cases with papillary thyroid carcinoma who accepted surgery treatment firstly in Tumor Hospital from Jan.1999 to Dec.1999. Patients were divided into different groups according to the plate let-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio(NLR) calculated from the peripheral venous blood,PLR<150 and PLR> 150 were classified as low and high PLR group,NLR<3 and NLR≥3 were classified as low and high NLR group,then compare their 15-year recurrence-free survival (RFS).Adopting the Cox model to analyze the data and evaluate whether PLR or NLR predicts risk of recurrence in patients with papillary thyroid carcinoma.Results:(1)The 15-year RFS of patients with low preoperative PLR(n=101) was significantly better than that of those with high preoperative PLR(n=34)(83.4% vs 45.4%).The difference of 15-year RFS between low preoperative PLR group and high preoperative PLR group was statistically significant(x2=18260, P<0.001).(2)The 15-year RFS of patients with lowpreoperative NLR(n=58) was significantly better than that of those with high preoperative NLR(n=77)(85.7% vs 64.1%).The difference of 15-year RFS between low preoperative NLR group and high preoperative NLR group was statistically significant(x2=7.146, P=0.008).(3)Choose the significant variables from the univariate analysis and then import them to Cox model to analyze again.Cox model showed that preoperative PLR and NLR are independent risk factor of prognosis.Conclusion:Preoperative PLR and NLR have the predicting value on recurrence-free survival in patients with papillary thyroid carcinoma. They are both convenient and economic indicators of test,preoperative blood routine analysis in patients can be achieved.Both PLR and NLR test won’t increase the economic burden of patients.and they are easy to calculate.Preoperative PLR> 150 or NLR≥3 predicts poorer prognosis of papillary thyroid carcinoma patients.