The Trail In The Regulation Function That Qi Bai Ping Fei Jiao Nang Capsule Has On"lung Qi Deficiency And Missing Management And Regulation " The COPD Pulmonary Vasoconstriction And The Clinical Research In To It

【Objective】Directed by the theory of The lung main gas and lung governing management and Regulation,the study is on interconnection between lung qi deficiency, loss of governance of the lung and Pulmonry vasoconstrcition. And it shows the mechanism of action between the lung qi deficiency and missing management and regulavion through clinical observaction and experimental study. In addition,it gives preliminary study on the curative effect of TCM onchronic obstructive pulmonary disease and the clinical effects on pulmonary vasoconstrcition as well as the target to provide new thinking methods to prevent and treat COPD,pulmonary arterial hypertension caused by worsened pulmonary vasoconstriction and pulmonary remodeling in TCM as well as to enrich the content of chronical obstructive pulmonary disease prevention and treatment in Chinese medicine science content to lay the foundation.【Method】The study is done by collating ancient and modern literature works,defining lung qi deficiency and missing management as regulation,and analyzing its significance in the development of COPD and through animal experiments.The researcher made the model by composite factors,combined with the establishment of a rat model of chronical obstructive pulmonary disease with phlegm and blood stasis syndrome and giving the rat Qi Bai Ping Fei Capsule.Observe the difference between before prevention and treatment and after that without using Qi BaiPing Fei Capsule and the compare pulmonary function observed in the rat, Hemondynamics,the changes of pulmonary vascular morphology, ELISA,HIF-1α,the transcriptional level of RT-PCR detection of protein kinase a mRNA and after that compare the difference efficiancy among Qi Bai Ping Fei Capsule and Nicorandil.Clinically give Qi Bai Ping Fei Capsule and observe patients with chronic obstructive pulmonary disease,phlegm and blood stasis resistance pulmonary syndrome,TCM syndrome Points Hemondynamicsas well as the change of Borg within the distance of 6 minutes’ walking.【Results】(1)The animal experimental results showed that when treat 4 weeks there was no significant difference of pulmonary function of Qi bai pingfei capsule in improving model rats and reduce the level of serum ET-1 and HIF-1α levels and effect of Nicorandil, but Qi bai pingfei capsule better than Nicorandil when intervene 4weeks.(2) Pathological examination showed Qibai Pingfei capsule can obviously reduce the inflammatory cell infiltration in lung tissue of rats and the proliferation of smooth muscle cell hypertrophy, there was no significant difference between Qi bai pingfei capsule and Nicorandil when intervene and treat 4 weeks.(3) Qibai Pingfei capsule can decrease the transcription level in lung tissue of rats with PKC-α mRNA compared with model group, P<0.01 or P<0.05,and there was no significant difference between Qi bai pingfei capsule and Nicorandil when intervene and treat 4 weeks.(4)After intervene and treat 4 weeks,stopping using Qi Bai Ping Capsule 4 weeks, the researcher found out that Qi Bai Ping Capsule was better than Nicorandil in improving pulmonary function,lowering mean carotial pressure(mCAP)and the level of serum HIF-1α and the transcription level in lung tissue of rats with PKC-α mRNA,but there was no difference in lowering mean pulmonary arterial pressure(m PAP) and the level of serum ET-1.(5) In clinical study,it can obviously reduce the mean pulmonaryarterial pressure and TCM syndrome Points and greatly improve the quality of life.【Conclusion】Lung Qi deficiency and missing management andregulation is themain pathogenesi of chronic obstructive pulmonary disease. The use of Qi Bai Ping Fei Capsule can preventtreat chronic obstructive pulmonary disease and truncate the course of its further development.and blood stasis obstructing the Lung;loss of governance of the lung;Pulmonary vasoconstriction...