Ganglioside To Research On The Effects Of Brain Damage, Brain Stem Auditory Evoked Potential

The research background and purpose:Pediatric brain damage is pointed out that before and after infancy, due to the central nervous system injury caused by cerebral palsy, mental retardation, epilepsy, the symptom such as hearing impairment, visual impairment or syndrome.[1] With the progress of the perinatal and neonatal medicine, neonatal mortality decline year by year, but the incidence of brain injury has a rising trend. Children with brain injury[2] the main clinical manifestations include:movement dysfunction, abnormal posture, muscle tension, an abnormal behavior can be associated with epilepsy, mental retardation and perceptual barriers and so on. Brain injury has become a One of the important reasons for disabled children in China, not only bring children with great pain of body and mind, for the society and family also bring huge economic burden and psychological stress. Infants and young children in a one-year-old brain system development is rapid, especially baby 6 months ago the nervous system is not yet mature, brain plasticity, on brain structure and function have good compensatory ability and strong ability of restructuring, has not yet materialized, specifically-damaged area function. The treatment of brain injury so far is still one of the worldwide medical problem, is one of the highlights in agro-scientific research in the field of neurological rehabilitation medicine. Although modern medicine for brain injury pathological study, etiology, and genetic diagnosis has made some progress, but still no big breakthrough on therapy. Therefore, seeking a new train of thought for the recovery of brain damage, drugs and methods to improve the quality of the survival of children with brain damage and reduce the resulting disability is the goal of the medical profession to children. While giving children with brain injury appropriate intervention, not only can adapt to the function of the nerve cells to compensate, and can restore the cerebral cortex and cerebellum cortical migration, to restore the energy metabolism of brain damage in children with brain nerve cells as early as possible, avoid or reduce the cell necrosis. But about intervention methods and the joint application of different interventions was still in the stage of exploration, and rehabilitation effect for children with intellectual level and different movement level and there is a big difference, so there is no unified recovery system. Clinical implementation of the early treatment of neurotrophic drugs, can be used to improve the symptoms of central nervous developmental disorders, for children with the entire exercise can improve have much impact, and intelligence to all sorts of brain injury and the recovery of brain function and secondary neurodegenerative has a protective effect. Analyzing cases of abnormal brainstem auditory evoked potential of children with brain injury in conventional rehabilitation training on the basis of sialic acid by the single four hexose ganglioside after treatment for brain stem auditory evoked potential impact. Aims at providing a basic clinical rehabilitation work with reference to evaluate rehabilitation treatmentResearch methods:This experiment was divided into control group,83 cases of 0 to 6 month, the experimental group 82 cases; 7-12 months in the control group 79 examples, the experimental group 81 cases. Gender, condition difference between experimental group and control group had no statistical significance.Control group given rehabilitation training (function training,30 min/second, the bid, 30 min/time job training, qd, massage,30 min/time qd, a course of treatment for 3 months)Based on the experimental group in the control group with single sialic acid four hexose ganglioside static drop (20 mg/day, continuous static drops 10 days,20 days of rest, stay three times for a period of treatment)In the control group and experimental group after 2 courses of treatment, review of brainstem auditory evoked potential.The results of the study:1.0-6 months of age group compared with control group, the application of ganglioside in children with brain stem auditory evoked potential has a certain improvement.2.7-12 months of age group compared with control group, the application of ganglioside in children with brain stem auditory evoked potential has no obvious improvement.3. on brain injury, early application of ganglioside on brainstem auditory evoked potential improvement is more obvious. Research conclusions:Brain injury, early application of ganglioside on brainstem auditory evoked potential improvement is more obvious.