Efficacy And Safety Of Dust Mite Sublingual Immunotherapy In The Treatment Of Allergic Rhinitis In Pediatric Patients:a Meta-analysis

Objective:To evaluate the efficacy and safety of dust mite sublingual immunotherapy(SLIT) in the treatment of allergic rhinitis in children.Methods: Randomized controlled trials about SLIT treating allergic rhinitis in pediatric patients were collected in PubMed,EMbase,Ovid,CBM, WanFang Data, CNKI, VIP from inception to May 20 Hand the Cochrane Library from inception to Issue5 2014.Two reviewers independently screened studies according to the inclusion and exclusion criteria, extracted data and evaluated the methodological quality of the included studies. Then meta-analysis was performed using the software RevMan 5.3. Results:A total of nine RCTs including 663 patients were finally included. The results of meta-analysis indicated that:the trial group was superior to the control group in reducing the scores of drug use (SMD=-0.61,95%CI-0.94 to-0.27, P=0.0004) and mite-specific serum IgE levels (follow-up time>22weeks:SMD=0.71,95%CI0.31 to 1.12, P=0.0005). However, no significant difference was found between the two groups in the scores of nasal symptoms (SMD=0.06,95%CI-0.13 to 0.25, P=0.55) and the incidence of adverse reaction (OR=13, 95%C/0.89 to 1.90,P=0.17).Conclusion:SLIT had less adverse events and better security, can also decrease the using frequency of antihistamine,β-aganist and nasal spray steroids.But SLIT was useless of decreasing the nasal symptoms and mite-specific serum IgE level for pediatric patients with allergic rhinitis.