| Purpose:To observe the changes of serum toxins, nitric oxide(NO), alanine aminotransferase(ALT), aspartate aminotransferase(AST), triglyceride(TG), total cholesterol(total cholesterol), clinical symptoms, body mass index(BMI), and liver B ultrasound results as well as adverse reactions of the patients with non-alcohol fat liver and treated by probiotics(enteric-coated bifida. triple viable capsules) combined with polyene phosphatidyl choline.Method:66 patients with medium or serious non-alcohol fat liver as well as increased transaminase and blood lipid and in conformity with the inclusion criteria and exclusion criteria were randomly divided into Group A and Group B. Among them there were 35 male patients and 31 female patients with the ratio of male to female as about 1.14:1. The youngest was 22 years old while the eldest was 60 years old with the average age as 42.58. The shortest course of disease of the patient was six months while the longest one was up to more than 15 years. The 33 patients in Group A were treated by polyene phosphatidylcholine capsules while the 33 patients in Group B were given enteric-coated bifida. triple viable capsules and polyene phosphatidylcholine capsules for treatment, and both groups were treated with normal exercising therapeutical methods and alimentary control. Analysis on the serum toxins, NO, ALT, AST, TG, TC, BMI, clinical symptoms, and liver B ultrasound results as well as adverse reactions were conducted for all patients before the treatment and 12 weeks after the treatment, and the SPSS computer statistical were taken to analyze the changing of the aforementioned indexes observed before and after the treatment.Results:As to the clinical symptoms, compared to the status of the two groups of patients before the treatment, those of them twelve weeks after the treatment had been significantly improved(P<0.05), and the clinical symptoms in Group B had been improved more significantly than those in Group A(P<0.05) with the comparative difference having statistical meaning. As to the BMI of the two groups of patients, those were significantly reduced compared to those before the treatment(P<0.05), and the BMI of Group B had been reduced to a degree more significantly of that of Group A(P<0.05) with the comparative differences of statistical meaning. As to the transaminase, there was no significant differences among the transaminases of the patients in Group A and Group B(P>0.05), and the transaminases of the patients in these two groups were all significantly reduced compared to those before the treatment(P<0.05); while the transaminases in Group B had been improved more than those in Group A(P<0.05), and the comparative difference was of statistical meaning. As to the blood lipid, there was no significant differences in the blood lipids of the patients in Group A and Group B(P>0.05), and the total cholesterols and triglycerides of all the patients after the treatment had been reduced compared to those before the treatment(P<0.05); while the total cholesterols and triglycerides in Group B had been improved more than those in Group A(P<0.05), and the comparative difference was of statistical meaning. As to the serum toxins and NO, there was no significant difference between the serum NO and endotoxins of the patients in Group A and Group B before the treatment(P>0.05), indicating that these two were of comparability. No significant changes occurred to the serum NO and endotoxins of Group A compared to those before the treatment(P>0.05), while the serum NO and endotoxins of Group B were reduced significantly compared to those before the treatment(P<0.05); in addition, after the treatment the serum NO and endotoxins of Group B were reduced significantly(P<0.05), and the comparative difference was of statistical meaning; and according to the linear correlation analysis, the serum NO was of positive correlation to the endotoxin(r=0.739, P<0.01). The overall effective rates of Group A and Group B were 73.3% and 90.3% respectively after twelve weeks of treatment, the overall effective rate of Group B was significantly higher than that of Group A, and the comparative difference was of statistical meaning. No obvious adverse reactions had been seen during the twelve weeks of treatment on the patients in the two groups. As to the adverse reactions, 2 patients in Group A had diarrhea(6.06%) and 3 patients(9.09%) were due to be unable to persist in exercise therapy and diet therapy. 1 patients in Group B had diarrhea(3.03%) who quit one week after the treatment and 1 patient(3.03%) was due to be unable to persist in exercise therapy and diet therapy.Conclusion:1. Single polyene phosphatidyl choline capsules in combination with exercise therapy and diet therapy may be applied to treat patients with medium or serious non-alcoholic fatty livers, which could reduce blood lipid and transaminase but played an insignificant role in reducing toxins and NO within serums.2. Probiotics in combination with polyene phosphatidyl choline capsule had been applied to treat medium and serious non-alcoholic fatty livers, which may better reduce blood lipid and transaminase as well as BMI in addition that the combined group had significantly increased total effective treatment rate, indicating that these two kinds of drugs had synergistic effects in in treating medium and serious non-alcoholic fatty livers.May significantly reduce the internal toxin and NO and are of active significance to the treatment of the NAFLD patients. |
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