| Background:Irritable bowel syndrome(IBS)is one of the most common functional gastroenterology diseases with high global prevalence,and its process is chronic or recurrent.The disease has influenced the quality of life of patients to varing degrees and brought severe social economical burdens.The mechanisms of IBS are still not clear,there has been more and more fundamental research and clinical research which suggest a positive correlation between various candidate genes and susceptibility of IBS.Recently the golden standard for diagnosis of IBS is the Rome III criteria,it is mainly dependent on cilinical sympotoms rather than changes in morphology or biochemistry,and lots of tests are required to exclude some organic deseases.Besides,the aim of terapy for IBS is to relieve symptoms,a lot of effort is still required to make process to personalized medicine. Therefore,research on susceptibility candidate genes is of great significance in specific markers for diagnosis and target treatment based in molecular level.At present,increasing studies support ADRA2A-1291C>G polymorphism is associated with visceral hypersensitivity,bowel movement and some somatic symptoms such as abdominal pain,abdominal distention,but there is conflict about whether ADRA2A-1291C>G polymorphism is related to IBS susceptibility.Objective:Case control studies or cohort studies about ADRA2A-1291C>G polymorphism and susceptibility of IBS are searched through network database PubMed and China National Knowledge Internet(CNKI),related datas are extracted and pooled with appropriate methods,analyes available studies with meta analysis and review the relatioinshiop between ADRA2A -1291C>G polymorphism and susceptibility of IBS,IBS-C,IBS-D,IBS-M.Methods:We searched for case-control studies in PubMed and CNKI until January 2015.P and I2 were used to assess the heterogeneity of case-control studies involved.Fixed effects model was used to pool the result if the test of heterogeneity was not significant, otherwise the random-effect model was selected.The associations under allele contrast model, codominant model, dominant model, and recessive model were analyzed. Odds ratios (OR) with 95% confidence interval (CI) of every study and overall studys was calculated.Result:A total of 4 articles with 606 IBS cases and 491 controls were included into our meta-analysis.G allele carrier was demonstrated to be a risk factor for IBS development in the overall population (C/C vs C/G+G/G, OR=0.73,95%CI(0.55, 0.97), P=0.03.CvsG:OR=0.85,95%CI (0.70,1.03), P=0.09; C/C vs G/G: OR=0.66,95%CI(0.42,1.04), P=0.07; C/G vs G/G:OR=1.11,95%CI (0.78,1.58), P=0.56; C/C+C/G vs G/G:OR=0.94,95%CI (0.67,1.31), P=0.71。In subgroup analysis based on every subtype of IBS, however, no significant associations are found between ADRA2A -1291C>G polymorphism and any subtype of IBS. Sensibility analysis shows that C/C vs G/G:OR= 0.646,95%CI=(0.427,0.976),P= 0.038.Conclusion:The results suggest that ADRA2A -1291C>Gpolymorphism especially G allele carriers confer susceptibility to the risk of IBS.Considering number of studies and cases involved was not large enough to support our standpoint,further well-designed studies are still needed. |
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