| BackgroundInfectious disease refers to the human body environment by bacteria, fungi, viruses and other pathogenic microorganisms steady change in a class of diseases, mostly by the patient during the treatment due to the body’s reduced ability to resist bacteria, poor health is caused by microbial invasion a series of pathophysiological changes of the disease. Now, with the development of medical technology, the popularity of antibiotics and public health, diagnosis and treatment of infectious diseases has undergone a significant change. Rational use of antibiotics can effectively treat a variety of bacterial infections or inhibit infection of pathogenic microorganisms, but overuse and misuse of antibiotics can lead to a large number of drug-resistant strains, it is a potential risk factor for clinical difficulty controlling bacterial infections occur. The abuse of antibiotics is very serious, therefore, essential to improve the diagnosis rate of infectious diseases and pathogen identification. Microscopy and bacterial culture is an important basis for diagnosis of bacterial infections, but clinical applications, there is often sampled complex, long bacterial culture period, the positive rate and other negative factors. For early diagnosis of bacterial infection, most commonly used in clinical laboratory diagnostic methods, including blood, C- reactive protein, erythrocyte sedimentation rate D- dimer and other inflammatory factors and other auxiliary differential diagnosis of infectious diseases and non-infectious diseases. However, these indicators are not high sensitivity and specificity for the presence of defects.ObjectiveOf serum procalcitonin levels and high sensitivity C- reactive protein levels in different parts of the infection, different strains of infection, infectious and non-infectious fever, severe hepatitis trends whether co-infection and its clinical significance.Methods209 cases of hospital infection department visits of the patients(55 cases of primary liver cancer, 50 cases of fever of unknown origin, cirrhosis 40 cases, 24 cases of severe hepatitis, liver abscess, 14 cases of other diseases such as other parts of the malignant tumor, abdominal abscess, pancreas inflammation, intestinal obstruction, cerebral infarction, chronic obstructive pulmonary disease, liver damage, a total of 26 cases), to collect clinical data of patients, their serum PCT concentrations of hs-CRP concentrations were measured to compare PCT and hs-CRP in different parts infection, differences in species infections, infectious diseases and non-infectious diseases between.Results1.Procalcitonin levels in different parts of the infection by the comparison: blood stream infection(5.55 ng / ml ± 6.32 ng / ml)> lung infection(3.43 ng / ml ± 6.70 ng / ml)> urinary tract infection(2.64 ng / ml ± 3.75 ng / ml)> liver abscess(2.63 ng / ml ± 2.06 ng / ml)> biliary tract infection(1.83 ng / ml ± 1.0ng / ml)> abdominal infection(1.15 ng / ml ± 1.37 ng / ml). ANOVA F = 3.035, p = 0.0124, the difference between groups was significant. Between different parts of the infected group hypersensitive C- reactive protein levels: blood stream infection(14.18 mg / L ± 2.25 mg / L), liver abscess(13.23 mg / L ± 3.45 mg / L), lung infection(12.50 mg / L ± 4.78 mg / L), biliary tract infection(12.49 mg / L ± 3.86 mg / L), urinary tract infection(12.33 mg / L ± 5.09 mg / L), abdominal infection(11.62 mg / L ± 5.05 mg / L). ANOVA no significant difference between the display group, F = 1.2, p = 0.31.2.Procalcitonin levels between different species comparison: Gram-negative bacteria(7.431 ng / ml ± 8.455 ng / ml)> fungal infections(4.475 ng / ml ± 3.557)> Gram-positive bacteria(2.305 ng / ml ± 2.363 ng / ml), the difference between Prescription: F = 5.316, p = 0.007, the difference was statistically significant. Among different strains hs-CRP levels: Gram-positive bacteria(13.06 ng / ml ± 2.808 ng / ml), Gram-negative bacteria(12.91 mg / L ± 4.890 mg / L), fungal infections(10.84 mg / L ± 5.523 mg / L), no difference between groups ANOVA, F = 2.031, p = 0.1376.3.Bacterial infections and non-infectious fever fever procalcitonin levels were(5.55 ng / ml ± 6.32 ng / ml)and(0.44 ng / ml ± 0.50 ng / ml). p = 0.0008, infection was significantly higher than non-infected group. Hs-CRP levels between the two groups was(14.18 mg / L ± 2.25 mg / L)and(11.71 mg / L ± 5.124 mg / L), p = 0.024, a statistically significant difference between groups. Infection and hypersensitivity reactions procalcitonin C- no correlation between protein, r = 0.21, p = 0.276.ConclusionProcalcitonin test has a certain value in the differential diagnosis of infectious diseases and non-infectious diseases; may determine the existence of early bacterial infections, has a good predictive value for sepsis and sepsis, and clinical antibiotic treatment. |
