Association Of The MIF Gene Polymorphism With Coronary Artery Disease In Han, Uygur And Kazakh In Chinese Xinjiang

Objectives:We aimed to investigate the association study of the MIF gene polymorphism with Coronary Artery Disease (CAD).Methods:We selected the case-control study of the three groups respectively. The CAD subject:coronary artery disease diagnosed by coronary angiography (Han population: 1140 people, Uygur population:960 people, Kazakh population:320 people). The control subject:gender-, age-matched normal healthy controls (Han population:1156 people, Uygur population:1200 people, Kazakh population:603 people). All CAD patients and controls were genotyped for the same three single nucleotide polymorphisms (rs755622, rs1007888, and rs2096525) of MIF gene by TaqMan SNP genotyping.Results:The study results of MIF gene showed that in total, man of Han and Kazakh population, the distribution of rs755622 genotypes showed a significant difference between CAD and control participants (P<0.05). The frequency of C allele was significantly higher in CAD group than that in control group(P< 0.05). In the Uygur population, rs755622 genotype and allele frequencies were no significant differences (P>0.05). The genotype and allele distribution of other two SNPs (rs1007888, rs2096525) showed no significant difference between CAD and control subjects in Han, Uygur and Kazakh (P>0.05). Logistic regression analysis showed that the CC+CG genotype of rs755622 was significantly higher in CAD patients than that in control subjects for the total, man of Han and Kazakh. In Han population, for total (OR=1.215, 95%CI=1.020-1.447,P=0.029), for man (OR=1.342,95%CI=1.063-1.694, P=0.014); In Kazakh population, for total (OR=1.746,95%CI=1.304-2.338, P<0.001), for man (OR= 1.993,95%CI=1.287-2.902,P=0.001).Conclusion:The present study suggested that the MIF gene rs755622 may be a genetic marker of CAD in man of Han and Kazakh.