Studying On BER Pathways Of XRCC1 Site SNP And Different Ethnic Groups Laryngeal Cancer Susceptibility In Xinjiang Han, Uygur And Kazak Nationalities

Objective:Researching on the base excision repair (BER) pathway of DNA repair gene XRCC1 bases mononuclear nucleotide polymorphism and the relationship between different ethnic groups laryngeal cancer susceptibility in xinjiang Han, Uygur and Kazak nationalities. Methods:Cases of XRCC1 Arg280His (rs25489) C/T (hybrid) and T/T (mutant) there was no statistically significant difference with control group in the proportion of the genotypes.A case-control study was performed on 58 patient with laryngeal squamous cell carcinoma and 120 random healthy control group. Multiplex SNaPshot technic was used to detect DNA base excision repair gene XRCC1 Gln632Gln (rs3547), Arg399Gln (rs25487), Arg280His (rs25489), Arg194Trp (rsl799782) loci single nucleotide polymorphism distribution in the case group and normal control group. Result: Three sites of the rest of the cases of XRCCl Gln632Gln (rs3547) C/T (hybrid) and T/T (mutant) genotype, Arg399Gln (rs25487) C/T (hybrid) and T/T (mutant) genotype, Arg194Trp (rsl799782) G/A (hybrid) and A/A (mutant) genotype is notably higher than that of control group (P<0.01). Gln632Gln (rs3547) C/T (hybrid) and T/T (mutant) genotype, Arg399Gln (rs25487) C/T (hybrid) and T/T (mutant) genotype, Arg194Trp (rsl799782) G/A (hybrid) and A/A (mutant) genotype ratio is significantly higher than control group (P<0.05) in cases ethnic group of Han.Uygur and Kazak nationalities, carrying (rs3547) C/T and T/T genotype, (rs25487) C/T and T/T genotype, (rsl799782) G/A and A/A genotype individual risk of laryngeal squamous cell carcinoma are added to the 0.96,1.74 and 1.39 times; 1.47,1.32 and 0.77 times; 1.49,1.51 and 1.56 times than XRCC1 (rs3547) C/C genotype, (rs25487) C/C genotype, (rsl799782) G/G genotype. Conclusion:Three national XRCC1 Gln632Gln, Arg399Gln, Arg280His, Arg194Trp loci polymorphism may be associated with laryngeal cancer genetic and there are differences, XRCC1 Gln632Gln, Arg399Gln, Arg194Trp locus mutation will lead to an elevated risk of throat cancer. XRCC1 Arg280His locus mutation has no statistically significant difference with the onset of throat cancer, may have nothing to do with the onset of laryngeal cancer on the site of mutation.