Study On The Relationship Between Metabolic Syndrome And Its Components And The Increased Prevalence Of Type 2 Diabetes, A Case-control Study

Objective1. To explore the relationship between metabolic syndrome(Mets) and its components and Type 2 diabetes(T2DM).2. To explore the relationship between aggregation degree of components of Mets and T2DM.Subjects and methods1. A case-control study based on frequency matching was conducted in a community in Jiaozuo city. A total of 327 people with T2DM diagnosedapp:addword:diagnosed by the municipal hospital and 517 controls from the same community with cases were enrolled in the study by random selection from May to October in 2011. All respondents were interviewed by a questionnaire and accepted physical examination. All participants provided written informed consent.2. The contents of questionnaire included gender, age, race, occupation, smoking history, history of drinking and eating habits and family history of diabetes. Data on physical check including height, weight, waist circumference, systolic blood pressure (SBP) and diastolic blood pressure (DBP) was also obtained. Blood samples were collected and were frozen at -80℃. Triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and fasting plasma glucose were measured for all participants.3. Statistical analysis Software of Epidate3.0 was adopted to establish the database. Questionnaires were input by two individuals at the same time and were checked by the two individuals. SAS9.1 was used to analyze the data, and the significance level (2-side) was 0.05.Results1. Among the 844 participants,319 subjects were Mets suffers according definition of the international Diabetes Federation (IDF) and the prevalence rate was 37.80%. The rate in women was higher than in men (50.82% vs.27.91%). The prevalence rate of Mets components from high to low was elevated blood sugar, central obesity, elevated blood pressure, low HDL-C and high blood TG, and the prevalence rate was 57.70%,56.99%, 41.47%,36.02%,29.27% respectively. The prevalence rate of central obesity in women was higher than in men, but the prevalence rate of elevated blood pressure and low HDL-C were lower than in men (P<0.05). There was difference in the aggregation degree of components of Mets in women and in men (2=15.794, P=0.007).2. Compared with controls, the prevalence of elevated blood pressure of high TG and Mets in cases was significantly higher. However, no significantly differences were found in the prevalence rate of central obesity and low HDL-C between cases and controls. Subgroup analysis according to gender suggested that the prevalence of elevated blood sugar, elevated blood pressure, high TG levels, and the Mets in T2DM patients were higher than in controls in men. Moreover, in women, except for low HDL-C, there were significantly differences in the prevalence of components of Mets and prevalence of Mets between case and controls.3. Logistic analysis adjusted by age, gender, smoking, drinking, family history of T2DM, TC, and body mass index (BMI) revealed that people with Mets were more vulnerable to diabetes than people with no Mets. The risk of T2DM increased along with the increase of number of components of Mets. The results of analysis on relationship between one component of Mets and T2DM showed that central obesity is the risk factors (OR:2.447,95%CI:1.489-4.023). Participants with high TG were more likely to suffer T2DM.In men, compared with those with no one component, participants with the 2 components of Mets have higher risk to T2DM (OR:3.152 People with Mets were 3.16 times to T2DM than people without Mets (95%CI:1.724-5.791). For the components of Mets, the results showed that only high HDL-C was associated with increased risk of T2DM (OR:3.16,95%CI:1.724-5.791). In women, with the increase of number of Mets component, the risk of T2DM also increased. People with Mets were more vulnerable to diabetes than those with no Mets (OR:9.387,95%CI:4.515-19.517). For the components of Mets, only central obesity and high TG were the risk factors to T2DM and the OR (95%CI) was 8.23(3.45～19.633) and 1.824(1.013～3.283) respectively.,95%CI: 1.486～6.687).Conclusion1. The participants with Mets have a higher odd ratio for the T2DM than those without Mets.2. The risk of T2DM increased alone with the increase of number of Mets components. Obesity and high TG were the risk factors for T2DM in women. However, low HDL-C was the most important risk factors for T2DM in men.