Clinical Research Of Zhongfengjieyu Soup With Fluoxetine Treated Post-Stroke Depression

Background The incidence of Stroke has increased year by year, Post-Stroke Depression (PSD) also has the tendency to increase.Clinical anti-depression drugs to Western medicine mainly, adverse reactions often leads patients to stop or refuse to use the drug, thereby reducing the treatment complia-nce,aggravate the depressive symptoms, serious impact on the stroke of late rehabilitation training, again to increase the risk of re-Stroke. At present,many studies in based report card with combination of TCM and Western medicine treatment of Post-Stroke Depression after the clinical curative effect and the simple use of the efficacy of Western medicine quite, but the side effects of the drug relatively less. Through the review of the literature, to explore the pathogenesis of Post-Stroke Depression, while digging out more effective, safety, little side effect, with clinical Practical value high compound Chinese medicine is the traditional Chinese and Western medicine combined with cerebrovascular disease professional medical workers more important research tasks.Objective Evaluate the safety and efficacy of PSD by using the treating methods-Zhongfeng jieyu Soup combined with Fluoxetine Capsules.Method To Choose the Chinese and Western Medicine Department and Department of Internal Neurology Of First Affiliated Hospital Of Xinxiang Medical University included in the standard of Eighty-three cases of PSD,were divided into treatment group by given Zhongfengjieyu soup combined with Fluoxetine Capsules% control group given Fluoxetine by the random number-table -method,42 and 41 in each group.Treatment is commonly neurology anti platelet aggregation, promoting blood circulation to remove blood stasis therapy on a regular basis, such as merger of hypertension, hyperlipidemia and diabetes subjects give corresponding monitoring and treatment. Patients were assessed by Hamilton rating scale for depression (HAMD)、National Institute of Health stroke scale (NIHSS) and content of 5-HT and the treat emergent scale (TESS) after2、4 and 8 weeks treatment.Result1. Compared treatment and control group with no-therapy and post-treatment, efficient rates were 92.3% and 76.9%;2. Before treated of the two group scores(17.6±2.52)、(18.6±2.50),by using t-test(P>0.05), having of statistically no significant,after treated 2-4 and 8 weeks group of HAMD scores (15. 7±2.51)、(12.8±2.21)、(9.25±1.90)compared to the same point in time the control group (1 7.0±2.80)、(13.9±2.13)、(10.36±2.15) were difference having statistically significant(P<0.05);3. Before treated of the two group scores(21.4±3.48、(22.8±3.28),by using t-test(P>0.05), having of statistically no significant,after treated 2,4 and 8 weeks group of NIHSS scores (19. 9±3.34)、(16.7±3.50)、(12.9±2.36)compared to the same point in time the control group (2 1.4±3.49)、(18.4±3.67)、(15.7±3.58) were difference having statistically significant(.P<0.05);4. Before treated of the two group’ serum lever of 5-HT (335.8±9.40)、(331.2±11.24), by using t-test (P>0.05),having of statistically no significant,after treated 2,4 and 8 weeks gro up of 5-HT (368.6±13.15)、(406.9±18.42)、(455.0±15.37) compared to the same point in time the control group (362.2±14.67)、(399.2±11.62)、(445.7±18.07) were difference havi ng statistically significant(P<0.05);5. The two groups were having statistically significant(P<0.05) in the traditional Chinese m edicine syndrome.The efficient of treatment group was 94.9%compared with control group’s74. 4%;6. There still existed significant different on incidence of TESS significant reduction(P<0.0 5). Conclusion Zhongfeng jieyu soup combined with fluoxetine in the treatment of PSD curative e ffect significantly, less adverse reaction and its mechanism of action may and elevated serum 5- HT neurotransmitter levels.