A Investigation Of The Feasibility Study On The Impact Of TCM With Immune Function Reconstruction In HIV

PurposeKnow about related research status of immune reconstitution in the AIDS field, analysis inadequacies of existing research level and Summary Chinese medicine research progress in the AIDS immune reconstruction,To provide a theoretical basis for the feasibility of HIV immune reconstitution Function of Traditional ChineseMedicine.To observe the improvement of TCM symptoms, immune function and other indicators of HIV viral load of the patients with low viral load, low immunogenicity who has taken Mianyi No.2 granules after HAART, and to reserch and analysis of the results. After clinical observation,To evaluate the improvement of Mianyi No.2 granules on the efficacy and safety of immune function,In order to exploring that Mianyi No.2 granules is a safe, effective, easy to popularize traditional Chinese medicine in treating immune reconstitution after HAART therapy.To provide new evidence for the clinical optimization on treating immune reconstitution after HAART.MethodUsing literature survey method to collect the immune reconstitution literature in the field of AIDS more than 20 years, Aiming at the shortcomings of HAART therapy, and many other therapies, to tease out the research results of TCM In HIV immune reconstitution.According to the inclusion criteria,68 cases of low viral load, low immunity AIDS patients are screened out from HIV-positive patients after HAART therapy, and observe clinical efficacy with a period of 36 weeks. The follow-up points are Pre-treatment and post-treatment for the first week 4,12,24,36. to monitor the immune function (CD3, CD4, CD8, CD45RA, CD45RO and other T cell subsets), clinical symptoms and quality of life, Meanwhile urinalysis, liver and kidney function,electrocardiogram.and observe whether the subject of adverse reactions during the trial, to evaluate the safety of the medicine of Mianyi No.2 granules. After the test is completed, conducting the data collection, collation and using SPSS 19.0 system software for analysis.Results1 Literature findings1.1 theoretical understandingThe View of Body upright and Modern immune recognition antigen-antibody is consistent in the regulation of the body upright, protecting the body against the evils of violations. In the field of traditional Chinese medicine treatment of AIDS, We can analogize TCM "righteousness" to Western "immune" function.1.2 Chinese herbal medicine researchAIDS researchers have analyzed hundreds of commonly used herbs, and found that many traditional Chinese medicine, To some extent,could improve immune system of AIDS patients and inhibition of viral replication.1.3 Herbal extractsPolysaccharides, organic acids extract, glycosides, alkaloids, volatile oils, etc, can adjust and enhance immune function.1.4 Compound of TCMAfter years of animal experiments and clinical validation, we found that most traditional tonic traditional Chinese medicine, non-tonic and some Chinese herbal compound researched for HIV immune reconstitution are to some extent able to adjust or improve immune function.2 Clinical research results2.1 An Evaluation of the efficacy2.1.1 Comparison of the efficacy of clinical symptomsIn the 68 patients screened, a total of 68 subjects completed the test.compared to the TCM symptom score before treatment, The total efficiency of clinical symptoms and signs was 85.3%. In the first four weeks, the subjects of the symptoms and signs of 68 cases total score was significantly lower than that before treatment, but in the 12th,24th,36th week, the integral decline slows. The overall trend is that the clinical signs and symptoms integral is declining before the treatment, and the difference has statistically significant (P<0.05), which prompt Mianyi No.2 granules has a good effect in terms of improving the subjects’clinical symptoms and signs.2.1.2 Evaluation of immune reconstitution related indicators before and after the treatmentThe integration of immune reconstitution related indicators in the first four weeks visit any significant decline, but in the 12th,24th,36th week, the evaluation integral decline slows. But before and after treatment, subjects evaluated integration of immune reconstitution related indicators declined, the difference was statistically significant (P<0.05), which prompts that Mianyi No.2 granules is effective in reducing immune reconstitution related indicators.2.1.3 Evaluation of laboratory resultsBefore and after treatment, Laboratory tests efficacy of CD4+ total efficiency is 45.6%,the total efficacy of RA+ efficiency is 33.8%. Subjects after 36 weeks of treatment, patients CD3CD4+, CD45RA+ and other immunological tests indicators have slowly increased, compared with before treatment, the difference was statistically significant (P<0.05).2.1.4 The index change of immune function before and after the treatmentCompared with before treatment, CD3CD4+ detection value of the subject in the first 12 weeks, the difference was not statistically significant(P>0.05), which prompted that traditional Chinese medicine Mianyi No.2 granules has little change on CD3CD4+ in the first 12 weeks; However, when the first 24 weeks,36 weeks, compared with before treatment, the difference was statistically significant (P<0.05), prompted that the beginning of the first 24 weeks, the Mianyi No.2 granules increased immunity has a good effect on CD3CD4+. RA+detection value changes before and after treatment is similar with CD3CD4+.2.2 Safety EvaluationDuring the observation of the clinical trial, subjects dependence is better, this test did not occur associated with adverse reactions and side effects, the vital signs of a subject with no change before and after the test.The indications disease of AIDS did not occur on the subject during the test, blood, urine, liver and kidney function and biochemical tests electrocardiogram, chest X-ray and other aspects neither change significantly, Suggest that traditional Chinese medicine Mianyi No.2 granules is safe and reliable, no significant side effects, in the treatment of immune reconstitution after HAART.ConclusionThrough the recent TCM literature research of HIV immune reconstitution function,we found that Chinese medicine is effective in terms of HIV immune reconstitution, and has a high safety and controllability, less side effects, lower resistance rates.Mianyi No.2 granules can significantly improve clinical symptoms and signs and subjects related indicators of immune reconstitution through this experiment clinical observation. From the laboratory to observe indicators, the Mianyi No.2 granules can improve immune function indicators, especially in improving CD3CD4+、CD45RA+ aspect has a good effect, and the test did not occur this trial-related adverse reactions and side effects during the observation period.It can be seen that the Mianyi No.2 is a safe and effective medicine granules in treating HIV/AIDS patients’ immune reconstruction after the HARRT therapy...