| Objective: To study the incidence rate of extra-esophageal manifestations ofgastroesophageal reflux disease (GERD) and risk factors in Xinjiang. Methods: Theincidence rate of three kinds of extra-esophageal manifestations was compared betweenthe male and female GERD patients, and between Han and Uygur, the correlation wasanalyzed between the three extra-esophageal manifestations, and the risk factors for theincidence rate of extra-esophageal manifestations was explored by chi square test andLogistic regression. Results:①The total incidence rate of the three kinds ofextra-esophageal manifestations was47.01%in GERD patients in Xinjiang. The incidencerates of reflux laryngopharyngitis, cough and asthma were27.24%,15.67%and12.31%,respectively. The incidence rate of reflux laryngopharyngitis was higher than reflux coughand asthma (χ2=42.557, P=0.000; χ2=75.261, P=0.000), and the incidence rate of refluxcough was higher than reflux cough (χ2=5.023, P=0.025);②The total incidence rate(47.13％vs46.92％; χ2=0.005，P=0.944), incidence rate of reflux laryngopharyngitis(25.20％vs28.94％; χ2=1.870，P=0.172), incidence rate of reflux cough (17.42％vs14.21％; χ2=2.067，P=0.150) and incidence rate of reflux asthma (11.27％vs13.18％;χ2=0.902，P=0.342) were not statistically different between the male and female GERDpatients. For the male GERD patients, the incidence rate of reflux laryngopharyngitis washigher than reflux cough (χ2=8.823, P=0.003) and asthma (χ2=31.772, P=0.000), and theincidence rate of reflux cough was higher than reflux asthma (χ2=7.505, P=0.006). For thefemale GERD patients, the incidence rate of reflux laryngopharyngitis was higher thanreflux cough (χ2=65.444, P=0.000) and asthma (χ2=43.587, P=0.000), and the incidencerate of reflux cough was not statistically different from reflux asthma (χ2=0.261, P=0.610); ③The total incidence rate was lower in the GERD patients of Han than Uygur (45.94％vs52.85％；χ2=8.660，P=0.011), the incidence rate of reflux laryngopharyngitis was lowerin Uygur than Han (20.17％vs32.47％；χ2=12.844，P=0.000), and the incidence rates ofreflux cough and asthma were lower in Han than Uygur (12.34％vs20.18％, χ2=12.180,P=0.000;9.74％vs15.79％, χ2=6.897, P=0.009). For the GERD patients of Han, theincidence rate of reflux laryngopharyngitis was higher than reflux cough (χ2=71.794, P=0.000) and asthma (χ2=95.549, P=0.000), and the incidence rate of reflux cough was notstatistically different from reflux asthma (χ2=2.116, P=0.146). For the GERD patients ofUygur, the incidence rates of reflux laryngopharyngitis, cough and asthma were notstatistically different (χ2=3.844, P=0.146);④The total incidence rate (42.50％vs48.81％;χ2=2.448, P=0.118), incidence rate of reflux laryngopharyngitis (29.28％vs33.33％;χ2=1.160, P=0.282), incidence rate of reflux cough (10.00％vs14.28％; χ2=2.594,P=0.107) and incidence rate of reflux asthma (10.00％vs10.71％; χ2=0.084, P=0.772)were not statistically different between the male and female GERD patients of Han. Thetotal incidence rate (56.50％vs50.00％; χ2=1.904, P=0.168), incidence rate of refluxlaryngopharyngitis (22.00％vs15.62％; χ2=3.036, P=0.081), incidence rate of refluxcough (22.00％vs18.75％; χ2=0.736, P=0.391) and incidence rate of reflux asthma (16.00％vs15.62％; χ2=0.012, P=0.913) were not statistically different between the male andfemale GERD patients of Uygur. For the male and female GERD patients of Han, theincidence rate of reflux laryngopharyngitis was higher than reflux cough and asthma, andthe incidence rate of reflux cough was not statistically different from reflux asthma. Forthe male and female GERD patients of Uygur, the incidence rates of refluxlaryngopharyngitis, cough and asthma were not statistically different;⑤There was nocorrelation between the incidences of the three kinds of extra-esophageal manifestations(P=0.121,0.191,0.721);⑥Uygur, exertion, smoking, fed-upness, animal food, acor food,and high Gerd Q scores were statistically significant among the possible risk factors inGERD patients in Xinjiang. Conclusions:①The incidence rate of the three kinds ofextra-esophageal manifestations was high in GERD patients in Xinjiang;②There was nocorrelation between the incidences of the three kinds extra-esophageal manifestations ofGERD patients in Xinjiang;③Uygur, exertion, smoking, fed-upness, animal food, acorfood, and high Gerd Q scores were the risk factors of incidence of extra-esophagealmanifestations of GERD patients in Xinjiang. |
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