Natural History Of Cerebral Cavernous Malformations A Case Report And Literature Review

Cerebral cavernous malformations (CCM) are common vascular lesions of the central nervous system that predispose to seizures, focal neurological deficits and potentially fatal hemorrhagic stroke. There are two types of form:sporadic and familial forms, sporadic cases usually present with a single lesion and familial cases present multiple and evolutive lesions. Magnetic resonance imaging (MRI) is a highly sensitive diagnostic technique and CT scan is sensitive to hemorrhage. In this article, we reported a family of multiple cerebral cavernous malformations patients. A75-year-old man experienced recurrent hemorrhage events, a41-year-old man and a20-year-old woman who suffered from neurological symptoms, and two fortyish men with MRI finds but no symptoms. We conducted a PubMed search for natural history of cerebral cavernous malformations, and describe epidemiology, clinical presentation, and natural history of CMM in an attempt to elicit more cogent data so as to clarify hemorrhage rates and risk factors for bleeding, and discuss treatment strategy of cerebral cavernous malformations.