A Preliminary Study Of Magnetic Resonance Imaging Detection On Renal Allograft Of Normal Function

Objective:Through the study renal function is normal BOLD and DWI-MRI performance and the performance of its functional magnetic resonance imaging to make a comprehensive evaluation of functional magnetic resonance imaging in order to evaluate renal function provide the basis for applications.Method:1. Fifteen healthy volunteers underwent BOLD and DWI scanning, which were designed as a control group.2. A group of grafts with normal function, which were confirmed by clinical examination and laboratory tests, were included in the study. According to post-transplant time is divided into three groups:the first group of about half month after transplantation; second group of about1month after transplantation; third group about eighteen months after transplantation. 3. Using statistical software analysis, the data for different period transplanted kidney with normal control group were statistically analyzed.4. The similarities and differences were analysis statistically, the value of BOLD and DWI in the detection of renal function were conducted.Result:1. The cortical R2*(1/sec) of healthy control group was17.862±1.228/sec, and the medullary R2(1/sec) was33.216±7.948/sec, which was significantly higher than cortical R2*. There was significant difference between the cortical R2*and the medullary R2(P<0.05). Cortex and medulla ratio R2*value of healthy control group was0.565±0.128.2. In the graft group, the values of the cortical R2*and the medullary R2significant difference between the half month group and the one month group had no significant differences. The18-month group medullary R2*value was significantly increased, there was a significant difference (P<0.05) with half month group with one-month group, but cortical R2*was no significant difference. Compared with the healthy control group, the group of transplanted kidney R2*value were statistically significant decreased (P<0.05).3. Through ADC values of the statistical analysis, we found that the ADC values of18-month group were lower than the half month group and the one month group, with a statistically significant difference (P<0.05). Comparing the half month group and18-months group with the healthy control group, there was a significant difference (P <0.05) in ADC values. Conclusions1. ADC DWI and BOLD MRI can be more sensitive and timely responses to changes in oxygen metabolism in the kidneys.2With the extension of time after transplantation, hypoxia in graft were gradually increased, and gradually the movement of water molecules was restricted. ADC DWI and BOLD MRI may be an early response to changes in graft function in the case, and more early than the result of laboratory tests,and were more helpful for clinical anticipation on graft function, and more importantly, those were more simple and noninvasive means.