Study On The Clinical Features And The Risk Scoring System For The Complication Of Coronary Artery Lesion Of1036Pediatric Cases With Kawasaki Disease In Suzhou

Objective: To research the clinical features of1036pediatric cases withKawasaki disease（KD）from2006to2014in Suzhou,and to establish the riskscoring system for the complication of coronary artery lesion.Methods: Retrospective reviews focus on medical records of1036pediatricinpatients with KD from2006to2014from local hospitals including theChildren’s Hospital of Soochow University,Suzhou Municipal Hospital of theMinistry and the Eastern Hospital.Analysis were done to study the clinicalcharacteristics of Kawasaki disease. And according to whether complicatedwith CAL, analysis on the factors that may affect the occurrence of CAL bysingle factor analysis, analysis the significant risk factors by Logisticregression analysis, risk factors were selected to enter the regression equation,so as to establish Logistic regression model. To establishing a simple scoringsystem according to Logistic regression coefficient assignment of each riskfactor. To verify the simple scoring system for predicting the efficacy of KDcombined with CAL by using the ROC curve.Results: There are275inpatients diagnosed as KD combined with CAL among1036cases of children, the incidence rate is26.54%, the ratio of maleto female was2.53:1. The single factor analysis find that CRP、PLT、HB、PA、ALB、ESR、WBC、HCT、CK-MB、CHOL、Na+difference is statisticallysignificant. The Logistic regression analysis showed that erythrocytesedimentation rate (ESR)、platelet (PLT)、hemoglobin (HB)、albumin (ALB)finally entered the regression equation. The Logistic regressionmodel:P=ey(1+e)， y=∑β1×X1， y=0.30×ESR+0.56×PLT+0.36×HB+0.60×ALB. The simple scoring system that which can predict theoccurrence of KD combined with CAL risk degree is established.（1）ESR≥40mm/h（0.30points）；（2）PLT>300×109/L（0.56points）；（3）HB≤100g/L（0.36points）；（4）ALB≤37g/L（0.60points）.The total score ofthis simple scoring system is1.82points,0-0.76is divided into the low riskgroup,0.77-1.82is divided into high-risk group, the simple scoring system tothe area under ROC curve, sensitivity and specificity were0.620,85%,32.5%.Conclusions: The incidence of male cases with KD concomitant CAL is morethan that of female cases. In addition to fever, the most common clinicalmanifestations is conjunctival hyperemia, followed by chapped lips. CRP、PLT、HB、PA、ALB、ESR、WBC、HCT、CK-MB、CHOL、Na+are therisk factor of KD combined with CAL.And ESR≥40mm/h、PLT>300×109/L、HB≤100g/L、ALB≤37g/L are the independent risk factor of KD combined with CAL. The simple scoring system which is established inpredicting the occurrence of KD combined with CAL in childTen has a highersensitivity (85%), but low specificity (32.5%).