Epidemiologic Study Between Metabolic Factors And The Risk Of Breast Cancer

ObjectiveMetabolic factors have been suggested to be associated with breast cancer．However,the findings are inconsistent among studies. We selected the statistics from aLarge-scale epidemiological survey in Beijing to evaluate the association betweenmetabolic factors and breast cancer in Chinese women.MethodsWe conducted a case-control study.116Breast cancer cases and their348controlsmatched by age and menopausal status were selected from the same institution. Eightrelevant factors of metabolic syndrome were evaluated. Odds ratios (OR) and95%confidence intervals (CI) for the association were estimated by logistic regressionanalysis.Results1、Obesity, high blood glucose, high triglyceride, low high-density lipoproteincholesterol, high blood pressure, and metabolic syndrome all had tendencies to increasethe risk of breast cancer.2、Elevated postprandial blood glucose and HbA1C level were associated withincreased breast cancer risk(OR=1.80and1.83,respectively). 3、Postprandial blood glucose and HbA1C level were also associated with increasedbreast cancer risk(OR=1.07and1.30,respectively).4、After converting the FBG, PBG, HbAIC value by quartile level data, we found thatcompared with the control group,the risk of breast cancer in women whose PBG isabove10.40mmol/L or HbAIC above6.4%was elevated obviously (OR=2.13and1.95, respectively).ConclusionsPostprandial blood glucose and HbA1C level were significantly associated withbreast cancer risk. Actively controlling blood glucose could greatly reduce the breastcancer risk.