The Clinical Study Of Treating Vascular Cognitive Impaiment No Dementia Of Kidney Deficiency And Blood Stasis Syndrome With Shouwuyizhi Pill

Objective: To observe the clinical efficacy of Shouwuyizhi Pill in treating vascularcognitive impairment no dementia of kidney deficiency and blood stasis syndrome and toexplore its action mechanism. Provide new clinical basis for traditional Chinese medicinetreatment of vascular cognitive impairment no dementia, and to embodies the advantagesof traditional Chinese medicine syndrome differentiation treatment of vascular cognitiveimpairment no dementia.Methods: According to the random,60patients of vascular cognitive impairment nodementia diagnosis standards and differentiation of kidney deficiency and blood stasissyndrome were divided into treatment group and control group,30patients in eachgroup.Treatment group given conventional and Shouwuyizhi Pill treatment(1agent a day,2times a day),Control group given conventional and Nimodipine Pill treatment(1pills eachtime,3times a day), continuous take medicine for2months. In before and2months aftertreatment, respectively on two groups of patients with TCM syndrome, MMSE scale, ADLscale score, and detect the event related potential P300(ERP-P300)and homocysteine(Hcy),compare two groups of patients after treatment syndromes integral, MMSE scale,ADL scale score and event related potential P300and homocysteine (Hcy) change. Thecomparison of before and after treatment and curative effect between groups,the resultswere statistically analyzed. Evaluate the effectiveness and security of the Shouwuyizhi Pilltreatment of vascular cognitive impairment no dementia (kidney deficiency and bloodstasis syndrome).Results: Clinical research results show that, Total clinical curative effect comparison:The treatment group total effective rate was70%, control group total effective rate was 60%;TCM syndrome curative effect comparison: The treatment group total effective ratewas80%, control group total effective rate was53.33%; TCM syndrome integralcomparison: Two groups of patients after treatment of Syndrome integral were reduced,compare two groups, the treatment group than the control group have significantdifferences (P＜0.01); MMSE scale, ADL scale score comparison: Two groups of patientsafter treatment of MMSE scores were increased,ADL scores were reduced, compare twogroups, the treatment group than the control group have differences (P＜0.05); Eventrelated potential P300of comparison: Two groups of patients after treatment of eventrelated potential P300incubation period were shorten, amplitude were increased, comparetwo groups, the treatment group than the control group have differences (P＜0.05);homocysteine (Hcy) of comparison: Two groups of patients after treatment ofhomocysteine (Hcy) were decreased, compare two groups, the treatment group than thecontrol group have no difference (P＞0.05).Conclusion: The Shouwuyizhi Pill can significantly improve patients with vascularcognitive impairment no dementia of kidney deficiency and blood stasis syndrome of TCMsyndrome, cognitive function, daily life ability, shorten the incubation period of the eventrelated potential P300, increases amplitude of the event related potential P300, decreasehomocysteine (Hcy), slow or even prevent from VCIND developing to VaD,improve thequality of patients’s life, has the good clinical curative effect. Fill in kidney essence,remove blood stasis phlegm and Shouwuyizhi Pill was effective in the treatment ofvascular cognitive impairment no dementia in therapeutic principle and drugs.