Concurrent Versus Sequential Systemic Chemotherapy And Whole Brain Radiation Therapy For Brain Metastases In NON-Small Cell Lung Cancer Patients

Objective:This study aims to observe simultaneous, sequential radiotherapy and chemotherapy in the treatment of therapeutic effect and toxicity of non small cell lung cancer, to provide a reference for NSCLC patients with brain metastases.Methods:We collected45survival state of good NSCLC patients with brain metastases in Liuzhou Worker’s Hospital in2008January to2011December in Department of Oncology. All of them were treated for concurrent chemotherapy or sequential brain radiation.We conducted a retrospective review of them to analysis their survival rates, median survival time and adverse reactions after treatment.Results:All the patients were followed up.The median survival time of concurrent chemotherapy group and sequential chemotherapy group were respectively13.0months and10.0months,1year survival rates were39.8%and36.2%, the difference between two groups had no statistical significance (P>0.05). While2year survival rates had significant difference between these two groups, which were22.7%and13.0%(P=0.041).Adverse effects on the concurrent chemotherapy group of leukopenia and thrombocytopenia reduction rate were68.2%and31.8%, which in the sequential chemotherapy group were30.0%and34.8%; over the sequential chemotherapy group of white blood cells reduction rate is higher than the sequential chemotherapy group, the difference was statistically significant (P=0.011);and other adverse reactions were no statistical significance (P>0.05). Conclusions:Concurrent chemotherapy,which is worthy of further clinical observation,in the treatment of NSCLC brain metastases were better than sequential chemo radiotherapy trend, also patients reflected well.