The Prevalence Of Obstructive Sleep Apnea Hypopnea Syndrome In Type2Diabetes Mellitus And It’s Effects On Lipid Metabolism In Diabetes

Objectives:The primary aim of the current study was to assess the prevalence of OSAHS in a group of adults with T2DM. A secondary objective was to explore the relationship between OSAHS and dyslipidemia in patients with type2diabetes.Methods:A cross-sectional study of adults with T2DM recruited randomly from Gansu Provincial hospital inpatient department of diabetes. All study participants had a diagnosis of T2DM and were asked to wear an ApneaLink(ResMed Corp, San Diego, CA) screening device for OSAHS (AHI≥5events/h) overnight in the hospital. Serum lipid levels were measured using the Olympus AU-5400autoanalyzer by routine enzymatic methods.Results:One hundred and fifty patients were analyzed. There were84males and66females with a mean age of (59.91±11.14) years (range:29-80years). The overall OSAHS prevalence was68%(median apnea-hypopnea indes,8; range,0-76), Regarding the severity of OSAHS,37.3%,16.0%and14.7%had mild, moderate and severe OSAHS, respectively. Around92%of all subjects had at least one lipid abnormality. Most common (76.7%) form of dyslipidemia found in all participants was raised LDL-C. Hypercholesterolemia(42.2%vs20.8%, p<0.05) and Lower-HDL(52.9%vs33.3%,p<0.05) prevalence was higher in patients with OSAHS than those without. After adjustment for possible confounders, OSAHS remained independently associated with lower-HDL(odds ratio,2.359;95%confidence interval,1.261^4.414; P=0.007).Conclusions:This study showed that both OSAHS and dyslipidemia have a high prevalence in adults with T2DM. Our study confirmed the independent association between OSAHS and lower-HDL in diabetic subjects. After adjustment for confounding factors, both AHI and ODI were independent predictors of lower-HDL. We identified chronic intermittent hypoxia as potential mechanism.