CRIPT, FAM82B, RABEP1Gene Polymorphism Associated With Schizophrenia Research And Effects Of Antipsychotics On Glucose And Lipid Metabolism

Objective:Genome-wide association study found RABEP1gene polymorphism rs1058398and rs1065482, FAM82B gene rs13042and CRIPT gene rs3087822locus may be associated with schizophrenia,But more about the genetic polymorphisms associated with schizophrenia of the findings is unclear, This study selected patients with schizophrenia in Chinese Han population and normal control subjects as discussed above four polymorphisms on three genes and whether the Chinese Han schizophrenia.Simultaneous analysis comparing schizophrenic patients taking antipsychotic medication before blood glucose and lipid levels, and glucose and lipid metabolism further Preliminary correlation between genotype different sites. Methods:In this study, a case-control study, the case group choose between2009-2013were diagnosed Huai’an City, Jiangsu Province, the Third People’s Hospital for psychiatric inpatients2358cases of schizophrenia and control select communities healthy volunteers with area2139cases, the use of TaqMan probe technology for genotyping, cases and controls were compared genotype and allele frequency distribution.Further explore the gene-gene interactions.Comparison between2013Huaian City, Jiangsu Province, the Third People’s Hospital575cases of first admission of patients before and after four weeks of antipsychotic treatment GLU, changes in TG, TC, HDL, LDL’s.(3) Select575cases of hospitalized patients in the first genotyping results of the study, glucose and lipid metabolism compared between the different sites of genotype variation. Results:Rs13042polymorphism and schizophrenia gene locus FAM82B illness related to its A allele may be a protective factor prevalence of schizophrenia(P=1.750X10-7),OR (95%CI) as0.800(0.736-0.870).Rs3087822polymorphism and schizophrenia gene locus CRIPT illness related to its G allele may be a risk factor for schizophrenia (P=3.205×10-5), OR(95%CI) for the1.255(1.127-1.397). antipsychotic drugs can cause lipid disorders, hospitalized after fasting blood glucose tended to decrease (t=4.085, P=5.046×10-5), before cholesterol, triglycerides, low-density lipoprotein liter compared with treatment high (t=6.123, P=1.704×10-9; t=10.691, P=1.875×10-24; t=6.064, P=2.411×10-9). Conclusions:Rs13042A locus alleles FAM82B gene significantly reduces the risk of an individual suffering from schizophrenia, and rs3087822site CRIPT G allele of the gene will increase the risk of an individual suffering from schizophrenia. Schizophrenia taking antipsychotics new cases of blood glucose, blood lipids occurred four weeks after the change, increasing the risk of metabolic abnormalities in the course of clinical care tips which should pay full attention caused by antipsychotic drugs.