Research On The Relationship Between Acute Mountain Sickness And Original Inhabited Area Geographic Factors In Young Males

BackgroundAcute mountain sicknes（sAMS）is a special disease, which occurs in people who enter tohighland regions from low altitude areas. The occurrence of AMS related to geographicalenvironment，and seriously threatening people’ health. The pathogenesis and susceptiblepopulation screening has always been the hot spot of high altitude medicine research. Atpresent, most researches focus on pathophysiology, molecular biology and genetics, and fewinvestigates the relationship between AMS and geographical factors. Combining literaturestudies and former research, we found that there is a obvious difference in the adaptabilities toplateaun environments of people from different areas.ObjectiveTo understand the relationship between AMS and the geographical factors of originalinhabited areas in Chinese young men. we undertake systematic analysis studies on regionaldifferences in population from the angle of medical geography so as to provide novelmaterials for screening susceptible population and exploring novel research ideas andmethods.MethodTotal294young men came from low altitude were randomly selected, questionnaire wasconducted and military AMS standard was applied for diagnosis. The geographical andmeteorological data was collected and standardized, and all medical geographical indicatorswas clustered through fast clustering method. Multiple independent samples nonparametrictest was used to analyze AMS incidence and symptoms. Binary logistic regression was usedto analyze the relationship between10different geographical factors and AMS incidence andfigure out the risk factors for medical geographical differences of AMS. ResultsAMS incidence was52.04%(153people), with most commonly seen dizziness,headache, shortness of breath, chest tightness and lip empurples, the occurrence was89.54%,84.31%,66.01%,65.36%and60.78%, respectively. According to the geographicalmeteorological information,65counties are divided into five types, AMS incidence and theoccurrence of various symptoms in different categories have the obvious difference betweenvarious regions.Binary logistic regression analysis revealed that altitude was the onlygeographical risk factor (OR=0.998, p<0.05).ConclusionThere are significant medical geographic differences in the AMS incidence among youngmales from different regions. Among the population who entered plateau, peoples who livesin lower native altitude brings higher risk of AMS; therefore corresponding preventionsshould be adapted for those who come from low altitude in order to ensure their health andsafety.