Clinical Study On The Related Risk Factors Of Serum Omentin-1and Ischemic Stroke Coupled With MS

Background and Objective:As its incidence increases recently, cerebral vascular disease, cardiopathy and tumorhave been the deadly cause of the death, with the characteristics of substantial morbidity,disability and mortality. With the development of life standard and the changing of the lifestyle in modern society, more and more abnormalities in metabolism have been occurring topeople. Metabolic Syndrome (MS)is not one single disease but an umbrella term used todescribe a serial of diseases which are determined by both genetic and environmental factorsand have the symptom of insulin resistance(IR), including obesity, hypertension, diabetes,dyslipidemia and so on.Omentin-1is a new adipocytokine which is closed related to IR,however, the relationship between omentin-1and ischemic cerebrovascular disease has notbeen studied yet. This study investigated the relationship among the level of omentin-1inserum, IR and ischemic cerebrovascular disease by measuring the level of the serum ometin-1in the cerebral infarction coupled with MS or not.Method:This experiment consists of101cerebral infarction patients who have been extractedfrom the department of neurology in the first Bethune Hospital of Jilin University. Whileother32healthy persons are considered as the control group who are extracted from thePhysical Examination Center in the first Bethune Hospital of Jilin University, the sampleshave been separated into two experimental groups: MS group and non-MS group, accordingto the standard of diagnosis published by IDF. The levels of serum Omentin-1among thethree groups which are measured by ELISA have been comparatively analyzed; the riskfactors, including hypertension, diabetes, waistline, serum lipid parameter, smoking history,gender, age and so on, in the two experimental groups (MS group and non-MS group) havealso been comparatively analyzed; the relationship between omentin-1and the related risk factors, such as hypertension, diabetes, waistline and serum lipid parameter, have also beenanalyzed.This study101cases of acute cerebral infarction patients and divided intoprogressive ischemic stroke group and non progressive ischemic stroke group, whose serumlevels of Omentin-1were compared. All of the related data have been analyzed via theSPSS17.0.Results:(1)Among the normal control group, MS group and non-MS group, the difference of agehad no statistical significance by T test (P>0.05); Gender between the three groups ofchi-square test, the difference had no statistical significance (P>0.05);(2) Between the MSand the non-MS group’s history of diabetes, hypertension by chi-square test, the differencewas statistically significant (P <0.05), compared to the non-MS group, the MS patients withdiabetes, hypertension were more than the control group; And about smoking history bychi-square test, the difference had no statistical significance (P>0.05); Among the MS andnon-MS group of SBP, DBP, MAP, TG, waist circumference, by T test, the difference had nostatistical significance (P <0.01), MS group of SBP, DBP, MAP, TG and waist circumferencevalues are higher than the non-MS group; MS and non-MS group of HDL-C and serumlevels of Omentin-1, by T test, had statistically significant difference (P <0.05); HDL-Cvalue and serum level of Omentin-1in the MS group were lower than the non-MS group;(3)In hypertension and non hypertension group, diabetes and non-diabetic group by T test, thedifference of serum levels of Omentin-1was statistically significant (P <0.01), serumOmentin-1level significantly lower in hypertension group diabetes, respectively, comparedthe non-hypertension group, the non-diabetic group; Serum Omentin-1and blood pressureindex including SBP (r=0.53, P <0.01), DBP (r=0.37, P <0.01), the MAP (r=0.438, P <0.01) showed a negative correlation, as SBP, DBP,and MAP were higher, serum levels ofOmentin-1reduced; Serum Omentin-1and TG levels （r=-0.265，P<0.01）,waistcircumference (r=0.37, P <0.01) showed a negative correlation, as the higher TG, waistcircumference, lower serum levels of Omentin-1; Serum Omentin-1level and TC (r=0.076,P>0.076), HDL (r=0.15, P>0.15), LDL (r=0.086, P>0.086) had no correlation; OnSerum levels of Omentin-1and its related risk factors by multi-factor linear regressionanalysis, its correlation with hypertension was the strongest negative correlation (r=0.461, P<0.05); The next were diabetes (r=0.373, P <0.05), TG (r=0.209, P <0.05);(4) the MSand non-MS group’s risk factors by the multi-factor Logistic regression analysis resultsshowed that TG on admission and waist circumference for MS were independent for acute cerebral infarction,and were positively correlated; And Omentin-1is a dependent relatedfactor.(5)by the T test,serum Omentin-1in the group of PIS with the non-PIS group hadstatistically significant difference,(P <0.05); In the PIS group the level of serum Omentin-1is lower than the non-PIS; Beween the PIS group and the non-PIS group the difference in MSproportion merged by the chi-square test was statistically significant (P <0.01), and the PISgroup was significantly higher than the non-PIS group.Conclusion:(1) Omentin-1is related risk factor of ischemic cerebrovascular disease;(2) centralobesity(waist), diabetes, hypertension and dyslipidemia contribute to increase the risk ofischemic stroke in patients with MS; TG, waist are independently related.(3) Hypertension,diabetes, high TG and central obesity are related risk factors, serum Omentin-1andhypertension are the most related factors among them;(4) MS,serum Omentin-1are relatedrisk factors of PIS.