| Objective: To analysis clinical features the factors related to the prognosis,with mantle cell lymphoma(MCL), in order to improve the overall understanding of mantle cell lymphoma, guide clinical practice.Methods: clinical data,pathological evidence of 18 MCL patients admitted from July 2008 to July 2014 5 patients from Second Affiliated Hospital of Dalian Medical University was retrospective analysis of the clinical characteristics of these patients, treatment using Fisher’s exact test to compare cumulative survival rate, survival data and prognostic analysis using the product limit method(Kaplan-Meier method) survival curves were plotted, the single factor analysis using the log rank test(log-rank method) between the survival curves and compared with no significant difference. Multivariate analysis using the COX proportional hazard model analysis of influence of various factors on the clinical prognosis.Results: 18 cases of patients with about Second Affiliated Hospital of Dalian Medical University during the same period of non Hodgkin’s lymphoma(NHL) 6%(a total of 290 cases of NHL admitted in the same period), the median age was 65 years old, the male to female ratio was 3.5:1. Immunophenotype detection: 17 patients underwent CD5 detection: CD5 positive in 16 cases(88%), 1 cases with CD5 negative(5%); detection was performed in 15 patients of CD10: CD10 was negative in 14 cases(77%), CD10 positive in 1 cases(6%), 16 cases with CD23 detection, 4 cases CD23 positive(25%), 14 cases with CD23 negative(87%), 17 patients underwent cydylind1 examination: cydylind1 positive 17 cases; KI-67 detection in 16 cases: 6 cases of Ki-67 ≥30%(37.5%), < 30% in 10cases(62.5%), the median value of 15%(1%-40%). Clinical features: 18 male patients with 14 cases(77.8%), 4 cases of female(22.2%);In 18 patients, aged <65 years old in 8 cases(44.4%), more than 65 years old in 10 cases(55.6%); the MIPI score low risk in 6 cases(33.3%), 5 cases of intermediate(27.8%), 7 cases of high risk(38.9%); bone marrow involvement in 4 cases(22.2%) without invasion in 14 cases(77.8% ECOG score); 16 cases of 0-1 points(88.9%), 2 cases(11.1%); 2-4% B symptoms in 3 cases(16.7%) without B symptoms in 15 patients(83.3%); 10 cases of Ki-67 <30%(62.5%), Ki-67 ≥30 of 6cases(37.5%); LDH was normal in 2 cases(66.7%), abnormal in 6 cases(33.3%); WBC was normal in 14 cases(77.8%), abnormal in 4 cases(22.2%); LYM was normal in 12 cases(66.7%), abnormal in 6 cases(33.3%); 2 patients with clinical stage(Ann-Arbor stage I(11.1%), 5 cases of stage II(27.8%), III, IV in 4 cases(22.2) 7 cases(38.9%);The first method of treatment of chop in 8 cases(53.3%) CAVD2 cases(13.3%) in group R 5 cases(33.2) of each of the factors for Fisher’s exact test of single factor analysis and log-rank method was used to compare the differences of single factor analysis of different survival curves, the results found that age <65 years old and over 65 years group(p=0.036), the MIPI scores of low risk medium risk, high risk groups,(p=0.049), Ki-67 value added index <30% or greater than or equal to 30%(P=0.001), bone marrow invasion(p=0.006) and prognosis with, and sex, B symptoms, ECOG score, beta 2 microglobulin, LDH, WBC, LYM staging, treatment method for the first time, and there was no statistically significant difference after statistics.Conclusion:Patients aged <65 years old, the prognosis is relatively the prognosis of patients 65 years of age or older with good. The MIPI score in patients with the best prognosis group low risk, medium risk group, high risk group had the worst prognosis. The prognosis of patients with better immune phenotype in KI-67 value added index <30% is greater than or equal to 30%. Without bone marrow invasion by patients with a better prognosis than bone marrow invasion. |
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