The Vary, Significance And Correlation Of Procalcitonin And C-reactive Protein In Acute Exacerbations Of Chronic Obstructive Pulmonary Disease

Objective:To observe the vary and correlation of procalcitonin (PCT) and C-reactiv protein (CRP) in patients with an acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and evaluate the value of severity of AECOPD and diagnosis of AECOPD with pneumonia.Methods:A total of 219 patients with AECOPD from September 2013 to December 2014 in Respiratory department of the First Affiliated Hospital of Kunming Medical University were studied. AECOPD group (n=106) and AECOPD with pneumonia group (n= 113). The AECOPD group according to The Global Initiative Chronic Obstructive pulmonary Disease (GOLD) 2014 standard was divided into AECOPD-B group (n= 33), C group (n= 30), D group (n= 43).Their WBC count and N, PCT, CRP levels, hospital stays, days of anti-infection treatment, hospitalization expense were collected, then test the correlation among PCT, CRP and the rest of the indicators above for analysis respectively.Results:1. WBC count,N, PCT, CRP levels, hospital stays, days of anti-infection treatment, and hospitalization expense of AECOPD with pneumonia group were all higher more meaningful than AECOPD group. Differences between two groups were of statistically significance (P< 0.05).2. There was some positive correlation between PCT and hospital stays, days of anti-infection treatment, hospitalization expense (r= 0.32,0.32,0.231,P< 0.05), no correlation with WBC, N, and CRP (P> 0.05); and there was some positive correlation among CRP and WBC,N (r= 0.372,0.209, P< 0.05); no correlation with PCT, hospital stays, days of anti-infection treatment, hospitalization expense (P> 0.05) in AECOPD group.There was some positive correlation among PCT and WBC, N, CRP (r= 0.202、0.309、0.293, P< 0.05), no correlation with hospital stays, days of anti-infection treatment, hospitalization expense (P< 0.05), there was some positive correlation among CRP and WBC,N,PCT,(r= 0.29、0.35、0.293, P< 0.05), no correlation with hospital stays, days of anti-infection treatment, hospitalization expense (P> 0.05) in AECOPD with pneumonia group.3、There was a difference among AECOPD-B、C、Dgroups of PCT, no difference of CRP. PCT:D group> C group= B group, there was no statistically significance between B group and C group (P>0.017). There was statistically significance between B group and D group, C group and D group (P< 0.017)Conclusion:1. PCT may play a role in distinguish AECOPD with AECOPD with pneumonia when combined withWBC, N and CRP.2. PCT may have some value to hospital stays, days of anti-infection treatment, hospitalization expense to AECOPD. 3. PCT may have some value to value the severity of AECOPD.