Clinical Value Of Serum Copeptin And Procalcitonin In The Patients With Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Objective: To analyse the clinical value of serum copeptin and procalcitonin(PCT) in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:The serumal copeptin, procalcitonin, C-reactive protein were detected in 150 hospitalized AECOPD patients before and after the treatment.And to study the correlation above indexs with chronic obstructive pulmonary disease severity and the COPDAssessment Test(CAT), 6 minutes walk distance(6 MWD).Result:Comparing with after the treatment patients and healthy control group,serumal levels of the copeptin, PCT, CRP were significantly elevated in the patient with AECOPD before the treatment(t=4.798,Z =-6.356,Z=-7.492,P<0.01).Above indexs were significantly higher at after the treatment patients than healthy control group(t=4.809,Z=-5.415,Z=-4.495,P<0.01);Serum copeptin and CRP have a statistical significance in stable COPD classification(P<0.05), but the PCT had no difference(P>0.05).On further,, the level of Serum copeptin were increasing with the increase in the severity of the disease in a certain extent; The serumal copeptin were positively correlated with CAT(r=0.336, P=0.000),and were negatively correlated with 6 MWD(r=-0.350,P=0.000).Conclusions:Serum copeptin and PCT can assess the incidence of acute exacerbations of chronic obstructive pulmonary disease and its therapeutic effect;Serum copeptin can reflect the severity of AECOPD patients in a certain extent, and has certain clinical value to evaluate the quality of life in patients.