Studies On The Expression Of Tumor Infiltrating Dendritic Cells Marked By CD1A And CD83 In Breast Cancer And Its Correlation With Prognosis

Objective:To explore the expression of tumor infiltrating dendritic cells in breast tissues and study on its correlation with prognosis.Methods:85 cases of breast cancer tissues were collected and performed immunohistochemical detection of CD1a, CD83 expressions in TIDC of breast cancer tissues, to discuss its relationship with clinicopathological features including ER, PR, HER-2, TNM staging, diameter of tumor, transfer, neutrophils and lymphocytes ratio (NLR) of breast cancer, and further to understand the characteristics, functions, immune and anti-tumor mechanism of TIDC in breast cancer, so as to provide effective evidences for the metastasis and immune escape mechanisms of breast cancer.Results:There were 77 cases with CD1a positive in 85 cases of breast cancer tissues, and most TIDC expressing CD1a were distributed in tumor tissues, and less expressed in tumor stroma and surrounding tissues; there were 44 cases with CD83 positive in 85 cases of breast cancer tissues, and TIDC expressing CD83 were distributed in surrounding and interstitial tissues of tumors, and the general expression amount was less, with scattering distribution. CD1a, CD83 double positive and non-double positive expression had no correlation with transfer, PR, and NLR, and the difference was no statistically significant (P> 0.05), but they were correlated with ER, HER-2, TNM staging, diameter of tumor, and the difference was statistically significant (P< 0.05). The 2-year disease-free survival of patients with CD1a, CD83 double positive expression was significantly higher than that of patients with CD1a, CD83 non-double positive expression (P< 0.01). Non-double positive expression of CDla, CD83 was an independent factor affecting patients (P< 0.01). The relative risk of CD1a, CD83 non-double positive expression was 2.216, which was higher than 1, indicating that the prognosis was poor in patients with CD83 and CD1a non-double positive expression.Conclusion:The expressions of characteristic markers CD83 and CD1a of TIDC in breast cancer tissues are related with prognosis, and may be associated with immune escape mechanism of tumors, so they can be the reference indicators to detect the prognosis of breast cancer.