The Correlation Between SERPINB1and The Recurrence And Prognosis Of Hepatocellular Carcinoma

Background:SERPINB1(serine proteinase inhibitor, clade B, member1) is a fast reactive inhibitor against neutrophil protease and one of the most efficient inhibitors of neutrophil protease. At present, many studies have shown that SERPINB1played an important role in lung cancer, stomach cancer, breast cancer and so on, but the role of SERPINB1in HCC (hepatocellular carcinoma) is still unclear.Objective:This study aimed to examine the expression of SERPINB1in HCC, and analyze its correlation with clinical pathologic features and prognosis of HCC patients.Methods:The expression of SERPINB1in48pairs of HCC tissues and corresponding adjacent tissues was examined by immunohistochemistry method. The correlation between SERPINB1and the clinical pathologic features was analyzed by univariate analysis and prognostic significance was assessed by Kaplan-Meier survival analysis.Results:The results showed that SERPINB1was highly expressed in48pairs of HCC tissues compared with adjacent tissues (p=0.003). The high SERPINB1expression in HCC tissues was significantly associated with metastasis (p=0.033), age (p=0.041) and gender (p=0.041). Meanwhile, the Kaplan-Meier survival analysis showed that the high SERPINB1expression was significantly associated with disease-free survival time (p=0.014) and overall survival time (p=0.017). Univariate analysis showed that high expression of SERPINB1in HCC tissues was an independent factor for disease-free survival time (p=0.004) and overall survival time (p=0.010).Conclusion:SERPINB1was highly expressed in HCC, and correlated with metastasis of HCC, disease-free survival and overall survival of patients, so SERPINB1could be used as a potential molecular predictor for HCC prognosis.