Study On The Correlation Between Metabolic Syndrome With Related Factors And Colorectal Polyps

Objective: Colorectal polyps is a type of neoplasmprotrudes from intestinal mucosa, which is protrusion lesion of colorectal mucosaepithelium. According to the histopathology classification of Morsom, colorectal polyps can be divided into many pathologic types, including adenomatous, inflammatory, proliferative, hamartoma, lipoma, etc.,among which adenomatous polyp is the most common. Colorectal adenoma is now considered one of precancerous lesions of colorectal cancer,which has formed the array of “adenoma-cancer”. Nowadays the morbidity of colorectal cancer is increasing over years, among malignancy morbidity worldwide, it ranked the 3rd for the male and the 2nd for the female, and there is a 4.2% annual increase in China. There are not overt symptoms formost early phases of colorectal cancer, appearing symptoms are mainly digestive tract common symptoms, and it is often ignored by patients as clinical symptoms are not typical. It is expected to further decrease morbidity of colorectal cancer to early detect colorectal cancer and precancerous lesions and study its influencing factors with interference. Currently, it has been proved that metabolism syndrome is one of the risk factors of colorectal adenomatous polyp, and metabolism syndromewith its related factors are correlated with the occurence of colorectal polyps and colorectal polyps recurrence. There are few domestic reports on the study of metabolicsyndrome and colorectal polyps, especially fewer studies on non-adenomatouspolyp. This paper will further study the correlation between metabolicsyndrome with related factors and colorectal polyps, in order to further identify risk factors of occurrence of colorectal polyps,thus providing basis for preventing colorectal cancer.Methods:Selecting inpatients receiving colonoscopy in enteroscopy room of the third department of the first hospital affiliated with Dalian Medical University from April 20 th of 2011 to October 20 th of 2014 as subjects. Sorting relevant data of enteroscopy, recording diagnosis, polyp sizes, locations and pathology types. Dividing into groups of adenomatous colorectal polyp and non-adenomatous colorectal polyp based on pathology results, and choosing patients receiving colonoscopy with no abnormality seen as the control group. On the basis of anamnesis, imaging examination, etc., recording whether the patients suffer from hypertension, coronary disease, diabetes, hepatic adipose infiltration, and keeping an account of relevant biochemical examination information, including data of fasting blood-glucose, blood uric acid, total cholesterol, triglyceride(TG), high density lipoprotein(HDL), low density lipoprotein and so on. Applying spss 17.0 to analyze, conducting comparative analysis on group of adenomatous and group of non-adenomatous with the clinical data of control group respectively.Results:1. The average ages of patients of adenomatous and non-adenomatous groups are both higher than the control group, so statistical differences exist in both groups(P<0.05). The detection rates of male patients from adenomatous and non-adenomatous groups are 64.94% and 50% separately, which are both higher than that in the control group, but the adenomatous group difference is statistically significant. The non-adenomatous group is not statistically significant. 2. The average levels of cholesterol, triglyceride, low density lipoprotein of adenomatous and non-adenomatous groups are all higher than that of the control group, whereas the average levels of high density lipoprotein are lower. The differences of triglyceride and high density lipoprotein of adenomatous group are statistically significant(P<0.05), and low density lipoprotein and cholesterolare are not statistically significant(P>0.05). Only triglyceride difference of non-adenomatous group is statistically significant(P<0.05),the other three are not statistically significant(P>0.05). 3. The positive detection rates of hypertension, hepatic adipose infiltration and coronary disease of adenomatous group are 37.96%,25.77% and 8.76% respectively, which are all higher than that of the control group. Hepatic adipose infiltration and hypertension differences are statistically significant(P<0.05), but coronary disease is not statistically significant(P>0.05). The positive detection rates of hypertension, hepatic adipose infiltration and coronary disease of non-adenomatous group are 30.49%,17.07% and 8.53% respectively, higher than that of the control group, but the differnces are not statistically significant(P>0.05). 4. The detection rates of type 2 diabetes in groups of adenomatous and non-adenomatous are 25.77% and 15.85% respectively, higher than that of the control group, but only the adenomatous group is statistically significant(P<0.05). The average levels of fasting blood-glucoseof two groups are both higher than that of the control group, but with no statistical significance(P>0.05). 5. The average levels of blood uric acid of two groups are both lower than that of the control group, the differences are not statistically significant(P>0.05). 6. Multifactorial non-conditional logistic regression analysis demonstrates that gender, age, type 2 diabetes, TG, HDL are the risk factors causing adenoma in the adenomatous group, the values of OR are 1.939(95%CI is 1.192-3.154);1.043(95%CI is 1.021-1.066);2.287(95%CI is 1.192-4.390);5.993(95%CI is 3.438-10.447);3.936(95%CI is 01.193-8.098)respectively, here the value of P is less than 0.05. In the non-adenomatous group, age and TG are the risk factors, the values of OR are 1.054(95%CI is 1.026-1.082); 9.428(95%CI is 4.327-20.543)respectively, differences are statistically significant.Conclusion:Age, gender, hepatic adipose infiltration, hypertension, type 2 diabetes, triglyceride, high density lipoprotein are related to the occurrence of colorectal adenomatous polyp. Non-adenomatous polyp is merely related to age and triglyceride. Multi-factor regression analysis shows that gender, age, diabetes, TG and HDL are the risk factors of adenomatous polyp, as for non-adenomatous group, TG is the risk factor.