The Expression And Meaning Of Fractional Exhaled Nitric Oxide And Total Serum Ige In The Patients With Asthma And COPD Overlap Syndrome

Objective:The purpose is to discuss the expression and meaning of total serum IgE、 fractional exhaled nitric oxide in the patients with Asthma and COPD overlap syndrome (ACOS),finding a new way to diagnose and treat ACOS patients.Method:We analyzed date from 50 patients with acute bronchial asthma (A group) 50 patients with acute exacerbation of COPD (B group) and 50 Patients with acute exacerbation of ACOS(C group) of hospitalized patients in the first affiliated hospital of Kunming medical university respiratory medicine during May 2013 to January 2015. The items of each case we collected included age, sex, body mass index (BMI), smoking history, total serum IgE, the peripheral eosinophil count, fractional exhaled nitric oxide and Pulmonary function. Descriptive data were given as mean± standard deviation (X+S) . Continuous variables were checked for normal distribution using the Kolmogorov-Smirnov test and tested by analysis of one-way analysis of variance. Discrete variables were reported and compared by x2test or Fisher’s exact test where appropriate. The difference between the two groups used independent sample t-test. For correlation analysis the Pearson correlation coefficient was calculated if data fitted normal distributionResult:1.The level of FeNO of C group was higher than B group (P< 0.01), and the level of FeNO of A group was significantly higher than B group (P< 0.01), but there was no significant differences in the level of FeNO between C group and A group (P>0.05).2. The level o the total serum IgE of C group was higher than B group (P< 0.01), and the level of the total serum IgE of A group was significantly higher than B group (P< 0.01), but there was no significant differences in the level of the total serum IgE between C group and A group (P>0.05).3.The number of people who was with the high level of FeNO and the total serum IgE of C group was higher than B group (P< 0.01), and the number of people who was with the high level of FeNO and the total serum IgE of A group was significantly higher than B group (P< 0.01), but there was no significant differences in number of people who was with the high level of FeNO and the total serum IgE between C group and A group (P>0.05).4. The level o the peripheral eosinophil count of C group was higher than B group (P < 0.01), and the level of the peripheral eosinophil count of A group was significantly higher than B group (P< 0.01), but there was no significant differences in the level of peripheral eosinophil count between C group and A group (P>0.05).Conclusion:1. the level of FeNO of acute exacerbation of ACOS was higher than acute exacerbation of COPD, so the level of FeNO can be used in differentiation diagnosis between acute exacerbation of ACOS and acute exacerbation of COPD. But, there was no significant difference in the level of FeNO between acute exacerbation of ACOS and the acute bronchial asthma. So the level of FeNO can’t be used in differentiation diagnosis between acute exacerbation of ACOS and acute bronchial asthma.2. The mean level of the total serum IgE count of acute exacerbation of ACOS was higher than acute exacerbation of COPD, so the mean level of the total serum IgE count can be used in differentiation diagnosis between acute exacerbation of ACOS and acute exacerbation of COPD. But, there was no significant difference in the mean level of the mean total serum IgE count between acute exacerbation of ACOS and acute bronchial asthma. So the mean level of the total serum IgE count can’t be used in differentiation diagnosis between acute exacerbation of ACOS and acute bronchial asthma.3. The number of people who was with the high level of FeNO and the total serum IgE of acute exacerbation of ACOS was higher than acute exacerbation of COPD, so the high level FeNO and the total serum IgE can be used in differentiation diagnosis between acute exacerbation of ACOS and acute exacerbation of COPD. But, there was no significant difference in the number of people who was with the high level of FeNO and the total serum IgE between acute exacerbation of ACOS and acute bronchial asthma. So the high level FeNO and the total serum IgE can’t be used in differentiation diagnosis between acute exacerbation of ACOS and acute bronchial asthma.4. There were no significant differences in peripheral eosinophil count among acute exacerbation of ACOS, acute exacerbation of COPD and acute bronchial asthma. So the peripheral eosinophil can’t be used in differentiation diagnosis among acute exacerbation of ACOS, acute exacerbation of COPD and acute bronchial asthma.