In Different Period With COPD Patients Of T Lymphocyte Subsets, FIB And CRP Level Changes Of Correlation Analysis

Objective:Chronic Obstructive Pulmonary Disease(COPD) is a common Disease respiratory medicine, its pathogenesis is extremely complicated, according to the known bacterial infection is a major cause of COPD induced acute, c-reactive protein(CRP) is a typical acute reactive protein, can be used as a sensitive and accurate indicator of the inflammatory process. Fibrinogen(FIB) is a kind of main synthesized from liver cells and secreted into the blood clotting factors, common function is the important index for determining blood coagulation function and hemodynamics, is also a kind of acute phase proteins reaction, can be used as judgment before thrombus status, sexual inflammation of the airway and lung tissue damage index, in the acute stage can be increased obviously; T lymphocyte subsets include: CD3 +, CD4 +, CD8 + subsets, including CD4 +, CD8 + subsets is the hub of the immune system to self- adjusting, immunology often on CD4 + / CD8 + ratio as the organism cellular immunity function is a sign of health; COPD patients can be made of Pulmonary function(FEV1 % expected), through the detection of Acute aggravating period of patients with Chronic Obstructive Pulmonary Disease(AECOPD) and serum C- reactive protein stability, T cell subsets(CD4 + / CD8 +) and fibrinogen(FIB) of water changes, in order to investigate the relationship with COPD, by testing their levels and in different periods of Pulmonary function of COPD patients with early diagnosis and evaluation of curative effect of provides the certain theory basis.Results:1. Age, body mass index(BMI) in COPD group and healthy group, gender ratio, differences between smoking-people had no statistical significance(P>0.05), Comparable between these groups。2. According to the result s show that the COPD group and healthy group of CRP, FIB, T cell subsets(CD4 +/CD8 +) levels are not equal, and statistically significant difference(P < 0.05);And COPD exacerbations period group, CRP and FIB, T cell subsets(CD4 + / CD8 +) levels were higher than the other two groups(P < 0.05);COPD plateau group and the control group FIB and CRP, T cell subsets(CD4 +/CD8 +) level difference between no statistical significance(P > 0.05).COPD patients with acute aggravating period and the stabilization of serum FIB, CRP, T cell subsets(CD4 +/CD8 +) levels were significantly elevated in the control group. The difference was statistically significant(P < 0.05).Stability of FIB and CRP, T cell subsets(CD4 +/CD8 +) levels in the acute aggravating period were significantly decreased, the difference was statistically significant(P < 0.05);FIB and CRP and CD4 +/CD8 + levels and negatively correlated with FEV1 %(P < 0.05).3 COPD patients with acute aggravating period of CRP and FIB level, at 0.01 level(double side) on the correlation coefficient of r=0.0141, P > 0.01);CRP, T cell subsets(CD4 +/CD8 +) levels in 0.01 correlation coefficient r=0.033(P > 0.01);FIB, T cell subsets(CD4 +/CD8 +) levels in 0.01 correlation coefficient r=0.089(P > 0.01);Thus, three sets of testing factor in the period of COPD exacerbations level 2, there is no obvious correlation between the two.Conclusion : 1. Plasma fibrinogen(FIB), T lymphocyte subsets(CD4 + /CD8 +) and Creactive protein(CRP) concentration and FEV1 % has significant negative correlation. Plasma fibrinogen(FIB), T lymphocyte subsets(CD4 + / CD8 +) and Creactive protein(CRP) levels associated with the disease severity of COPD patients; Also has certain guiding significance for the prognosis of patients. 2. Joint detection of the above three levels of change for the diagnosis and curative effect of acute exacerbation of COPD estimate provides certain theoretical basis...